| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0066 | ||||
| Gene Name | ABCD4 | ||||
| Protein Name | Peroxisomal membrane protein 1-like | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JBJ_A_A Identity:95.27% Minimized Score:-1458.536 kcal/mol Detail: Structure Info |
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| Synonyms | ABC41; ABCD4; ATP-binding cassette sub-family D member 4; EST352188; MAHCJ; P70R; P79R; PMP69; PMP70-related protein; PXMP1-L; PXMP1L; Peroxisomal membrane protein 69 | ||||
| DT Family | ATP-Binding Cassette (ABC) Superfamily ; | ||||
| Tissue Specificity | Ubiquitous. | ||||
| Function | This transporter may be involved in intracellular processing of vitamin B12 (cobalamin) and it plays a role in the lysosomal release of vitamin B12 into the cytoplasm. | ||||
| Endogenous Substrate(s) | Cobalamin | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Peroxisomal membrane protein 1-like |
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(β) Cell Distribution Level of Peroxisomal membrane protein 1-like |
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(γ) Organelle Distribution Level of Peroxisomal membrane protein 1-like |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Peroxisomal membrane protein 1-like |
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(γ) Transcriptional Regulation of Peroxisomal membrane protein 1-like |
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(δ) Epigenetic Regulation of Peroxisomal membrane protein 1-like |
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(ε) Exogenous Modulation of Peroxisomal membrane protein 1-like |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Peroxisomal membrane protein 1-like |
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(β) Disease-specific Protein Abundances of Peroxisomal membrane protein 1-like |
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(γ) Species- and Tissue-specific DT Abundances |
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