| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0474 | ||||
| Gene Name | SLC7A7 | ||||
| Protein Name | Y+L amino acid transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JMQ_A Identity:49.293% Minimized Score:-1100.319 kcal/mol Detail: Structure Info |
||||
| Synonyms | Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1; SLC7A7 | ||||
| DT Family | Amino Acid-Polyamine-Organocation (APC) Family | ||||
| L-type Amino Acid Transporter (LAT) Family | |||||
| Tissue Specificity | Highest expression in kidney and peripheralblood leukocytes. Weaker expression is observed in lung, heart,placenta, spleen, testis and small intestine. Expressed in normalfibroblasts and those from LPI patients. Also expressed in HUVECs,monocytes, retinal pigment epithelial cells, and various carcinomacell lines, with highest expression in a colon-carcinoma cellline. | ||||
| Function | This transporter Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. And it plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. | ||||
| Endogenous Substrate(s) | Amino acids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Y+L amino acid transporter 1 |
|||||
|
(β) Cell Distribution Level of Y+L amino acid transporter 1 |
|||||
|
(γ) Organelle Distribution Level of Y+L amino acid transporter 1 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Y+L amino acid transporter 1 |
|||||
|
(γ) Transcriptional Regulation of Y+L amino acid transporter 1 |
|||||
|
(δ) Epigenetic Regulation of Y+L amino acid transporter 1 |
|||||
|
(ε) Exogenous Modulation of Y+L amino acid transporter 1 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Y+L amino acid transporter 1 |
|||||
|
(β) Disease-specific Protein Abundances of Y+L amino acid transporter 1 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.