Drug Transporter (DT) Information

General Information of DT
DT ID DTD0416
Gene Name SLC59A1
Protein Name Major facilitator superfamily domain-containing protein 2A
Gene ID
26227
UniProt ID
Q8NA29
TCDB ID
2.A.2.3.8
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms 3-PGDH; 3PGDH; HEL-S-113; MFSD2; MFSD2A; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA; Sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1
DT Family Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family ;
Function This sodium-dependent lysophosphatidylcholine (LPC) transporter plays an essential role for blood-brain barrier formation and function. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
Endogenous Substrate(s) Tunicamycin
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Major facilitator superfamily domain-containing protein 2A
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Major facilitator superfamily domain-containing protein 2A
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Major facilitator superfamily domain-containing protein 2A
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Major facilitator superfamily domain-containing protein 2A
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Major facilitator superfamily domain-containing protein 2A
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Major facilitator superfamily domain-containing protein 2A
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Major facilitator superfamily domain-containing protein 2A
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Major facilitator superfamily domain-containing protein 2A
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Major facilitator superfamily domain-containing protein 2A
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Docosahexaenoic acid
 Phase 3 Drug Info Alzheimer disease 8A20 [1]
References
1 Mfsd2a Is a Transporter for the Essential -3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14.

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