Drug Transporter (DT) Information

General Information of DT
DT ID DTD0359
Gene Name SLC42A3
Protein Name Ammonium transporter Rh type C
Gene ID
51458
UniProt ID
Q9UBD6
TCDB ID
1.A.11.4.1
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:3HD6_A

Identity:100%

Minimized Score:-1250.417 kcal/mol

Detail: Structure Info

Synonyms C15orf6; CDRC2; PDRC2; RHCG; RHGK; Rh family type C glycoprotein; Rh glycoprotein kidney; Rh type C glycoprotein; Rhesus blood group family type C glycoprotein; SLC42A3; Tumor-related protein DRC2
DT Family Ammonium Transporter Channel (AMT) Family ;
Function This transportr may regulate transepithelial ammonia secretion and mediates the transport of electroneutral and bidirectional ammonium.
Endogenous Substrate(s) NH4+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Ammonium transporter Rh type C
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Ammonium transporter Rh type C
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Ammonium transporter Rh type C
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Ammonium transporter Rh type C
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Ammonium transporter Rh type C
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Ammonium transporter Rh type C
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Ammonium transporter Rh type C
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Ammonium transporter Rh type C
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Ammonia
 Preclinical Drug Info Coronary artery disease BA6Z [1]
References
1 Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47.

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