Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0299 | ||||
| Gene Name | SLC35D2 | ||||
| Protein Name | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter | ||||
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| UniProt ID | |||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | HFRC; HFRC1; Homolog of Fringe connection protein 1; SLC35D2; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8 | ||||
| DT Family | Drug/Metabolite Transporter (DMT) Superfamily | ||||
| UDP-glucuronate/UDP-N-acetylgalactosamine Transporter (UGnT) Family | |||||
| Tissue Specificity | Highly expressed in heart, kidney, smallintestine, placenta, lung and peripheral blood leukocyte. Weaklyexpressed in skeletal muscle and spleen. Not expressed in brain,colon and thymus. | ||||
| Function | This antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). | ||||
| Endogenous Substrate(s) | GDP-mannose; UDP-N-acetylglucosamine | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(β) Cell Distribution Level of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(γ) Organelle Distribution Level of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(γ) Transcriptional Regulation of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(δ) Epigenetic Regulation of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(ε) Exogenous Modulation of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(β) Disease-specific Protein Abundances of UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.