Drug Transporter (DT) Information

General Information of DT
DT ID DTD0198
Gene Name SLC25A36
Protein Name Solute carrier family 25 member 36
Gene ID
55186
UniProt ID
Q96CQ1
TCDB ID
2.A.29.10.6
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms PNC2; SLC25A36; Solute carrier 25 member 36
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Expressed at moderate level.
Function This transporter is mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate).
Endogenous Substrate(s) Pyrimidines
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Solute carrier family 25 member 36
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Solute carrier family 25 member 36
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Solute carrier family 25 member 36
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Solute carrier family 25 member 36
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Solute carrier family 25 member 36
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Solute carrier family 25 member 36
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Solute carrier family 25 member 36
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Solute carrier family 25 member 36
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Solute carrier family 25 member 36
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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