Drug Transporter (DT) Information

General Information of DT
DT ID DTD0169
Gene Name SLC25A11
Protein Name Mitochondrial 2-oxoglutarate/malate carrier
Gene ID
8402
UniProt ID
Q02978
TCDB ID
2.A.29.2.13
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2LCK_A

Identity:33.562%

Minimized Score:-438.832 kcal/mol

Detail: Structure Info

Synonyms OGC; OGCP; SLC20A4; SLC25A11; Solute carrier family 25 member 11
DT Family Mitochondrial Carrier (MC) Family ;
Function This transporter catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis.
Endogenous Substrate(s) Malate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial 2-oxoglutarate/malate carrier
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial 2-oxoglutarate/malate carrier
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial 2-oxoglutarate/malate carrier
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Mitochondrial 2-oxoglutarate/malate carrier
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial 2-oxoglutarate/malate carrier
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial 2-oxoglutarate/malate carrier
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial 2-oxoglutarate/malate carrier
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial 2-oxoglutarate/malate carrier
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial 2-oxoglutarate/malate carrier
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.