Drug Transporter (DT) Information

General Information of DT
DT ID DTD0115
Gene Name SLC17A2
Protein Name Sodium-dependent phosphate transport protein 3
Gene ID
10246
UniProt ID
O00624
TCDB ID
2.A.1.14.29
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6V4D_A

Identity:35.695%

Minimized Score:-724.643 kcal/mol

Detail: Structure Info

Synonyms NPT3; Na(+/PI cotransporter 3; SLC17A2; Sodium/phosphate cotransporter 3; Solute carrier family 17 member 2
DT Family Major Facilitator Superfamily (MFS)
Anion:Cation Symporter (ACS) Family
Tissue Specificity Expressed in the small intestine, kidney,spleen and testis. Not detected in fetal brain, bone marrow, andmammary gland.
Function This transporter may be involved in actively transporting phosphate into cells via Na(+) cotransport.
Endogenous Substrate(s) Na+; Phosphate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent phosphate transport protein 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent phosphate transport protein 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent phosphate transport protein 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-dependent phosphate transport protein 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent phosphate transport protein 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent phosphate transport protein 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent phosphate transport protein 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent phosphate transport protein 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent phosphate transport protein 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Aminohippuric acid
 Withdrawn Drug Info Renal function tests MG02 [1]

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           9 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-NPT3 Km =0.4 microM [1]
References
1 Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Am J Physiol Cell Physiol. 2015 Jul 15;309(2):C71-80.

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