Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0503 Transporter Info
Gene Name SLCO4C1
Transporter Name Organic anion transporting polypeptide 4C1
Gene ID
353189
UniProt ID
Q6ZQN7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in breast cancer condition [1]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLCO4C1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in breast cancer condition [1]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLCO4C1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO4C1 gene in megakaryocytes condition [2]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLCO4C1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4C1.

       Transcriptional Phenomenon2

 Direct binding to SLCO4C1 gene [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO4C1 gene in uremia condition [4]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Affected Drug/Substrate

 Guanidinosuccinate

Studied Phenotype

 Uremia [ICD11: GB6Z]

Tissue

 Kidney

Related DT Changes

 Down regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to repress the transcription of SLCO4C1 gene in uremia condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 4C1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

        GLIS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [5]

TF Protein Name

 Zinc finger protein GLIS1 Transcription Factor Info

Tissue

 Blood; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein GLIS1 (GLIS1) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [6]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [7]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in health condition [8]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLCO4C1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO4C1 gene in breast cancer condition [9]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLCO4C1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 4C1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NANOG 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in HESC condition [10]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLCO4C1 gene in HESC condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.

       Transcriptional Phenomenon2

 Binding to SLCO4C1 gene in health condition [11]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLCO4C1 gene in health condition, which leads to a affected expression of the drug transporter Organic anion transporting polypeptide 4C1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [12]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLCO4C1 gene in . condition, which leads to a affected expression of the drug transporter Organic anion transporting polypeptide 4C1.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in breast cancer condition [13]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLCO4C1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO4C1 gene in embryonic stem cell condition [14]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLCO4C1 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 4C1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO4C1 gene [7]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLCO4C1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 4C1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO4C1 gene in prostate cancer condition [15]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLCO4C1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 4C1.
References
1 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
2 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. PLoS One. 2013 Jul 9;8(7):e66518.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-400. (ID:ENSG00000173930)
8 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
9 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
10 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
11 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
12 Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
13 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
14 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
15 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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