Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0476 Transporter Info
Gene Name SLC7A9
Transporter Name Glycoprotein-associated amino acid transporter b0, +AT1
Gene ID
11136
UniProt ID
P82251

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.3: Basic helix-span-helix factors

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        TFAP2A 

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       Transcriptional Phenomenon1

 Binding to SLC7A9 gene in health condition [1]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC7A9 gene in health condition, which leads to an affected expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Direct binding to SLC7A9 gene [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC7A9 gene in . condition, which leads to a affected expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.

        HNF4A 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A9 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC7A9 gene in health condition, which leads to an affected expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.

       Transcriptional Phenomenon2

 Binding to SLC7A9 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC7A9 gene in health condition, which leads to an affected expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC7A9 gene in erythroleukemia condition [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC7A9 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1B 

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       Transcriptional Phenomenon1

 Activation of SLC7A9 gene in renal cysts condition [6]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC7A9 gene in renal cysts condition, which leads to an increased expression of the drug transporter Glycoprotein-associated amino acid transporter b0, +AT1.
References
1 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
2 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
3 Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol. 2009;9:68.
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.

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