Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0464 Transporter Info
Gene Name	SLC7A11
Transporter Name	Cystine/glutamate transporter
Gene ID	23657
UniProt ID	Q9UPY5

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC7A11 gene in glioblastoma multiforme condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC7A11 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Cystine/glutamate transporter.
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in breast cancer condition			[2]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC7A11 gene in breast cancer condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[3]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in coronary artery disease condition			[5]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC7A11 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
JUND		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in coronary artery disease condition			[5]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC7A11 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Direct binding to SLC7A11 gene			[6]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Brain; Cervix; Colon; Coronary artery; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
NFE2L2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in health condition			[7]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Affected Drug/Substrate	Cystine
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	Up regulating
Experimental Material	129/SvJ mice
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of SLC7A11 gene in health condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Activation of SLC7A11 gene in glioblastoma condition			[8]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Glioblastoma [ICD11: 2A00.00]
Tissue	Brain
Related DT Changes	up regulating
Experimental Material	Human glioblastoma cells
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous tetrathiomolybdate, has been reported to activate the transcription of SLC7A11 gene in glioblastoma condition , which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in melanoma condition			[9]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC7A11 gene in melanoma condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in glioblastoma multiforme condition			[10]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC7A11 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in prostate cancer condition			[11]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the SLC7A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Binding to SLC7A11 gene in prostate cancer condition			[12]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC7A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon3	Binding to SLC7A11 gene			[13]
TF Protein Name	Androgen receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC7A11 gene in . condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon4	Activation of SLC7A11 gene in health condition			[14]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Uterus
Related DT Changes	up regulating
Experimental Material	Sprague-Dawley pregnant rats
Detailed Description	Androgen receptor (AR), influenced by the exogenous flutamide, has been reported to activate the transcription of SLC7A11 gene in health condition , which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in health condition			[15]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC7A11 gene in health condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC7A11 gene in myofibroblast condition			[16]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC7A11 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Cystine/glutamate transporter.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in hematopoiesis condition			[17]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC7A11 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Direct binding to SLC7A11 gene			[6]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in hematopoiesis condition			[17]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC7A11 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[18]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Bone marrow; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in health condition			[19]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC7A11 gene in health condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
FOXA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in prostate cancer condition			[20]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC7A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Direct binding to SLC7A11 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[18]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[6]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in health condition			[19]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC7A11 gene in health condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in hepatoblastoma condition			[21]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Transcription factor p65 (RELA), influenced by the exogenous aspirin, has been reported to activate the transcription of SLC7A11 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC7A11 gene in epithelial to mesenchymal transition condition			[22]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC7A11 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Transcriptional Phenomenon2	Binding to SLC7A11 gene in health condition			[23]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC7A11 gene in health condition, which leads to an affected expression of the drug transporter Cystine/glutamate transporter.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[4]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[18]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC7A11 gene in human embryonic stem cells (hESCs) condition			[24]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC7A11 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Cystine/glutamate transporter.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC7A11 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC7A11 gene, which in turn affects the expression or function of the drug transporter Cystine/glutamate transporter.

References
1	In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
3	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-326. (ID:ENSG00000151012)
5	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
6	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
7	Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem. 2002 Nov 22;277(47):44765-71.
8	Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway. Anticancer Drugs. 2020 Jan;31(1):27-34.
9	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
10	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
11	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
12	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
13	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
14	Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway. FEBS Lett. 2022 Mar;596(6):806-825.
15	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
16	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
17	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
18	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
19	Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
20	SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
21	Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-kappaB p65-activated SLC7A11 transcription. Acta Pharmacol Sin. 2023 Aug;44(8):1712-1724.
22	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
23	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
24	Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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Detail Information of Transcriptional Regulations

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