Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0451 Transporter Info
Gene Name SLC6A19
Transporter Name Sodium-dependent neutral amino acid transporter B(0)AT1
Gene ID
340024
UniProt ID
Q695T7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        HIF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in hypoxia condition [1]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to bind to the transcription of SLC6A19 gene in hypoxia condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in melanoma condition [2]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC6A19 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A19 gene in coronary artery disease condition [3]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC6A19 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in glioblastoma multiforme condition [4]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC6A19 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in health condition [5]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Human kidney human embryonic kidney 293 cells (HEK 293)

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to activate the transcription of SLC6A19 gene in health condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        VDR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in leukemia condition [6]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC6A19 gene in leukemia condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

       Transcriptional Phenomenon2

 Binding to SLC6A19 gene in THP-1 human monocytic leukemia cells condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC6A19 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in health condition [8]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC6A19 gene in health condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

       Transcriptional Phenomenon2

 Binding to SLC6A19 gene in megakaryocytes condition [9]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC6A19 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in hematopoiesis condition [8]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC6A19 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in gastric cancer condition [10]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC6A19 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in erythroleukemia condition [11]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC6A19 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in gastric cancer condition [10]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC6A19 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A19 gene in health condition [5]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Human kidney human embryonic kidney 293 cells (HEK 293)

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC6A19 gene in health condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in prostate cancer condition [12]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC6A19 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

        FOXP2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in health condition [13]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC6A19 gene in health condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A19 gene in epithelial to mesenchymal transition condition [14]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC6A19 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT1.
References
1 High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011;117(23):e207-17.
2 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
3 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
4 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
5 Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. J Biol Chem. 2013 Nov 22;288(47):33813-33823.
6 Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
7 Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
8 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
11 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
12 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
13 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
14 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.

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