Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0440 Transporter Info
Gene Name SLC6A1
Transporter Name Sodium- and chloride-dependent GABA transporter 1
Gene ID
6529
UniProt ID
P30531

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFIL3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in epileptic seizures condition [1]

TF Protein Name

 Nuclear factor interleukin-3-regulated protein Transcription Factor Info

Studied Phenotype

 Epileptic seizures [ICD11: 8A60-8A6Z]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 Rev-erba KO mice

Detailed Description

 Nuclear factor interleukin-3-regulated protein (NFIL3) has been reported to activate the transcription of SLC6A1 gene in epileptic seizures condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in colorectal cancer condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC6A1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC6A1 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Androgen receptor (AR) has been reported to repress the transcription of SLC6A1 gene in prostate cancer condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

       Transcriptional Phenomenon2

 Binding to SLC6A1 gene in prostate cancer condition [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC6A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A1 gene in health condition [5]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC6A1 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

        NR1D1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in epileptic seizures condition [1]

TF Protein Name

 Nuclear receptor subfamily 1 group D member 1 Transcription Factor Info

Studied Phenotype

 Epileptic seizures [ICD11: 8A60-8A6Z]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 Rev-erba KO mice

Detailed Description

 Nuclear receptor subfamily 1 group D member 1 (NR1D1) has been reported to activate the transcription of SLC6A1 gene in epileptic seizures condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

        THRA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in hypothyroidism condition [6]

TF Protein Name

 Thyroid hormone receptor alpha Transcription Factor Info

Studied Phenotype

 Hypothyroidism [ICD11: 5A00.2]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Wistar rats

Detailed Description

 Thyroid hormone receptor alpha (THRA) has been reported to activate the transcription of SLC6A1 gene in hypothyroidism condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in podocyte condition [7]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC6A1 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in HESC condition [8]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC6A1 gene in HESC condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in ovarian cancer condition [9]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC6A1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXO3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in tumorigenesis condition [10]

TF Protein Name

 Forkhead box protein O3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC6A1 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in prostate cancer condition [11]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC6A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A1 gene in human embryonic stem cells (hESCs) condition [12]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC6A1 gene in human embryonic stem cells (hESCs) condition, which leads to a increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 1.
References
1 Dysregulation of REV-ERBalpha impairs GABAergic function and promotes epileptic seizures in preclinical models. Nat Commun. 2021 Feb 22;12(1):1216.
2 Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
3 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
4 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
5 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
6 Influence of thyroid hormone and thyroid hormone receptors in the generation of cerebellar gamma-aminobutyric acid-ergic interneurons from precursor cells. Endocrinology. 2007 Dec;148(12):5746-51.
7 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
8 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
9 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
10 Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
11 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
12 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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