Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0387 Transporter Info
Gene Name	SLC4A7
Transporter Name	Sodium bicarbonate cotransporter 3
Gene ID	9497
UniProt ID	Q9Y6M7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in hypertension condition			[3]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Studied Phenotype	Hypertension [ICD11: BA00]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human peripheral blood mononuclear cell isolates
Detailed Description	Protein c-Fos (FOS) has been reported to activate the transcription of SLC4A7 gene in hypertension condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
ASCL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	Achaete-scute homolog 2		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 2 (ASCL2) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Tissue	Brain; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene in HL60 condition			[6]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC4A7 gene in HL60 condition, which leads to an affected expression of the drug transporter Sodium bicarbonate cotransporter 3.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC4A7 gene in prostate cancer condition			[7]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC4A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium bicarbonate cotransporter 3.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in atherosclerotic foam cells condition			[8]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	T0901317
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC4A7 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
NR3C1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC4A7 gene in health condition			[9]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Bronchus
Related DT Changes	Down regulating
Experimental Material	human bronchial epithelial cell isolates
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to repress the transcription of SLC4A7 gene in health condition, which leads to a decreased expression of the drug transporter Sodium bicarbonate cotransporter 3.
PGR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Progesterone receptor (PGR) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in breast cancer condition			[10]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Krueppel-like factor 4 (KLF4) has been reported to activate the transcription of SLC4A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC4A7 gene in breast cancer condition			[10]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Down regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to repress the transcription of SLC4A7 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Sodium bicarbonate cotransporter 3.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in podocyte condition			[11]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC4A7 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC4A7 gene in breast cancer condition			[12]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC4A7 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium bicarbonate cotransporter 3.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
HNF1B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in renal cysts condition			[13]
TF Protein Name	Hepatocyte nuclear factor 1-beta		Transcription Factor Info
Studied Phenotype	Renal cysts [ICD11: GB80]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Zebrafish TgPT::EGFP)
Detailed Description	Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC4A7 gene in renal cysts condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ELK1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in health condition			[14]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to activate the transcription of SLC4A7 gene in health condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
Transcriptional Phenomenon2	Binding to SLC4A7 gene in health condition			[15]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of SLC4A7 gene in health condition, which leads to an affected expression of the drug transporter Sodium bicarbonate cotransporter 3.
Transcriptional Phenomenon3	Direct binding to SLC4A7 gene			[4]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Tissue	Blood; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[1]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[2]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC4A7 gene in health condition			[16]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC4A7 gene in health condition, which leads to an affected expression of the drug transporter Sodium bicarbonate cotransporter 3.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC4A7 gene in prostate cancer condition			[17]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC4A7 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium bicarbonate cotransporter 3.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[4]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC4A7 gene			[5]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC4A7 gene, which in turn affects the expression or function of the drug transporter Sodium bicarbonate cotransporter 3.

References
1	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-146. (ID:ENSG00000033867)
3	The Hypertension Risk Variant Rs820430 Functions as an Enhancer of SLC4A7. Am J Hypertens. 2017 Feb;30(2):202-208.
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6	Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008;36(21):e144.
7	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
8	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
9	Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells. BMC Med Genomics. 2019 Jan 31;12(1):29.
10	ErbB2 upregulates the Na+,HCO3(-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4. FASEB J. 2014 Jan;28(1):350-63.
11	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
12	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
13	Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
14	Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009;19(11):1963-73.
15	ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
16	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
17	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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Detail Information of Transcriptional Regulations

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