Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0321 Transporter Info
Gene Name	SLC36A4
Transporter Name	Proton-coupled amino acid transporter 4
Gene ID	120103
UniProt ID	Q6YBV0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[1]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Bone marrow; Breast; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[2]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[3]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[2]
TF Protein Name	Androgen receptor		Transcription Factor Info
Tissue	Cervix; Kidney; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Androgen receptor (AR) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[3]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Blood; Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[4]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC36A4 gene in health condition			[5]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC36A4 gene in health condition, which leads to an affected expression of the drug transporter Proton-coupled amino acid transporter 4.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC36A4 gene in health condition			[6]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC36A4 gene in health condition, which leads to an affected expression of the drug transporter Proton-coupled amino acid transporter 4.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[1]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[1]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC36A4 gene in fibrosarcoma condition			[7]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of SLC36A4 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Proton-coupled amino acid transporter 4.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC36A4 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC36A4 gene, which in turn affects the expression or function of the drug transporter Proton-coupled amino acid transporter 4.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-415. (ID:ENSG00000180773)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5	Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
6	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
7	Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.

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Detail Information of Transcriptional Regulations

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