Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0298 Transporter Info
Gene Name SLC35D1
Transporter Name UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
Gene ID
23169
UniProt ID
Q9NTN3

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        CEBPD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein delta Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in coronary artery disease condition [5]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC35D1 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in coronary artery disease condition [5]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC35D1 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC35D1 gene in medulloblastoma condition [6]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC35D1 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [5]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        HNF4G 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 4-gamma Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        GATA3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in breast cancer condition [7]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC35D1 gene in breast cancer condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

       Transcriptional Phenomenon2

 Direct binding to SLC35D1 gene [4]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood; Brain; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        BCL6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [3]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Tissue

 Blood; Tonsil

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [2]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [2]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in health condition [8]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC35D1 gene in health condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in prostate carcinoma condition [9]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC35D1 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

       Transcriptional Phenomenon2

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [4]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [4]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35D1 gene [2]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC35D1 gene, which in turn affects the expression or function of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in health condition [10]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC35D1 gene in health condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35D1 gene in HaCaT keratinocytes condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC35D1 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-231. (ID:ENSG00000116704)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
6 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
7 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
8 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
9 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
10 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
11 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.