Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0285 Transporter Info
Gene Name SLC34A2
Transporter Name Sodium-dependent phosphate transport protein 2B
Gene ID
10568
UniProt ID
O95436

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC34A2 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC34A2 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Sodium-dependent phosphate transport protein 2B.

      Class1.2: Basic helix-loop-helix factors

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        MYC 

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       Transcriptional Phenomenon1

 Binding to SLC34A2 gene in embryonic stem cells condition [2]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC34A2 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Sodium-dependent phosphate transport protein 2B.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        NR1I2 

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       Transcriptional Phenomenon1

 Activation of SLC34A2 gene in hypophosphatemia condition [3]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Affected Drug/Substrate

 Inorganic phosphate

Studied Phenotype

 Hypophosphatemia [ICD11: 5C64.3]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Pxr KO mice

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of SLC34A2 gene in hypophosphatemia condition, which leads to an increased expression of the drug transporter Sodium-dependent phosphate transport protein 2B.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC34A2 gene in fibrosarcoma condition [4]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC34A2 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Sodium-dependent phosphate transport protein 2B.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC34A2 gene in human embryonic stem cells (hESCs) condition [5]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC34A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Sodium-dependent phosphate transport protein 2B.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC34A2 gene in hESCs condition [5]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC34A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Sodium-dependent phosphate transport protein 2B.
References
1 In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
3 Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2. Pharmacogenet Genomics. 2010 Jan;20(1):9-17.
4 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
5 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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