Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0282 Transporter Info
Gene Name	SLC33A1
Transporter Name	Acetyl-coenzyme A transporter 1
Gene ID	9197
UniProt ID	O00400

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
ATF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-2		Transcription Factor Info
Tissue	Blood; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
ATF3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC33A1 gene in glioblastoma multiforme condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC33A1 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
CREB1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in health condition			[6]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of SLC33A1 gene in health condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in health condition			[6]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Protein c-Fos (FOS) has been reported to activate the transcription of SLC33A1 gene in health condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in health condition			[6]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Transcription factor Jun (JUN) has been reported to activate the transcription of SLC33A1 gene in health condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
XBP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in astrocytoma condition			[7]
TF Protein Name	X-box-binding protein 1		Transcription Factor Info
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human astrocytoma cells (H4)
Detailed Description	X-box-binding protein 1 (XBP1) has been reported to activate the transcription of SLC33A1 gene in astrocytoma condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Tissue	Brain; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
EPAS1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in duodenal adenocarcinoma condition			[8]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Studied Phenotype	Duodenal adenocarcinoma [ICD11: 2B80.00]
Tissue	Duodenum
Related DT Changes	Up regulating
Experimental Material	Human duodenal adenocarcinoma cells (HuTu 80)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC33A1 gene in duodenal adenocarcinoma condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Activation of SLC33A1 gene in colon cancer condition			[8]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Up regulating
Experimental Material	Human colon adenocarcinoma cells (Caco-2)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC33A1 gene in colon cancer condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in melanoma condition			[9]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC33A1 gene in melanoma condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in embryonic stem cells condition			[10]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC33A1 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in glioblastoma multiforme condition			[11]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC33A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[12]
TF Protein Name	Androgen receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC33A1 gene in . condition, which leads to a affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Activation of SLC33A1 gene in castration-resistant prostate cancers condition			[13]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of SLC33A1 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in health condition			[14]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC33A1 gene in health condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in health condition			[15]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC33A1 gene in health condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Blood; Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
KLF10		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Krueppel-like factor 10		Transcription Factor Info
Tissue	Breast; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 10 (KLF10) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
SALL4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in health condition			[16]
TF Protein Name	Sal-like protein 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Sal-like protein 4 (SALL4) has been reported to bind to the transcription of SLC33A1 gene in health condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in multiple human cancer types condition			[17]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC33A1 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC33A1 gene in embryonic stem cell condition			[18]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC33A1 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
EHF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	ETS homologous factor		Transcription Factor Info
Tissue	Bronchus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS homologous factor (EHF) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
ETS1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC33A1 gene in T cell activation condition			[19]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Protein C-ets-1 (ETS1) has been reported to activate the transcription of SLC33A1 gene in T cell activation condition, which leads to an increased expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in megakaryocytes condition			[20]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC33A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Umbilical cord blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[3]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow; Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[1]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[5]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC33A1 gene in HaCaT keratinocytes condition			[21]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC33A1 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Acetyl-coenzyme A transporter 1.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC33A1 gene			[4]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC33A1 gene, which in turn affects the expression or function of the drug transporter Acetyl-coenzyme A transporter 1.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-388. (ID:ENSG00000169359)
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6	The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway. J Neurochem. 2020 Aug;154(4):404-423.
7	SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway. J Biol Chem. 2012 Aug 24;287(35):29921-30.
8	Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2alpha. FEBS Lett. 2012 Jul 30;586(16):2423-7.
9	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
10	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
11	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
12	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
13	Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153-63.
14	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
15	Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
16	SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
17	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
18	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
19	DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet. 2009;5(12):e1000778.
20	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
21	Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.

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