Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0252 Transporter Info
Gene Name	SLC2A10
Transporter Name	Glucose transporter type 10
Gene ID	81031
UniProt ID	O95528

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ASCL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	Achaete-scute homolog 2		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 2 (ASCL2) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in melanoma condition			[4]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC2A10 gene in melanoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in embryonic stem cells			[5]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Up regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to activate the transcription of SLC2A10 gene in embryonic stem cells, which leads to an increased expression of the drug transporter Glucose transporter type 10.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in glioblastoma multiforme condition			[7]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC2A10 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in prostate cancer condition			[8]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of SLC2A10 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
Transcriptional Phenomenon2	Binding to SLC2A10 gene in prostate cancer condition			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC2A10 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A10 gene in breast cancer condition			[10]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Estrogen receptor beta (ESR2) has been reported to repress the transcription of SLC2A10 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Glucose transporter type 10.
NR3C1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in ER(-) breast cancer condition			[11]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC2A10 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A10 gene in metabolic disorders condition			[12]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC2A10 gene in metabolic disorders condition, which leads to a decreased expression of the drug transporter Glucose transporter type 10.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in erythroleukemia condition			[13]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC2A10 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in podocyte condition			[14]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC2A10 gene in podocyte condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in breast cancer condition			[15]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC2A10 gene in breast cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
ZNF76		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Zinc finger protein 76		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 76 (ZNF76) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
DUX4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Double homeobox protein 4		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Double homeobox protein 4 (DUX4) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
ISL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A10 gene in diabetes mellitus condition			[16]
TF Protein Name	Insulin gene enhancer protein ISL-1		Transcription Factor Info
Affected Drug/Substrate	Insulin
Studied Phenotype	Diabetes mellitus [ICD11: 5A10-5A14]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Insulin gene enhancer protein ISL-1 (ISL1) has been reported to activate the transcription of SLC2A10 gene in diabetes mellitus condition, which leads to an increased expression of the drug transporter Glucose transporter type 10.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in MCF7 cells			[17]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC2A10 gene in MCF7 cells, which leads to an affected expression of the drug transporter Glucose transporter type 10.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein O3 (FOXO3) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ELK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in health condition			[18]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of SLC2A10 gene in health condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Blood; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	GastroIntestine tract
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
SPDEF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[3]
TF Protein Name	SAM pointed domain-containing Ets transcription factor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	SAM pointed domain-containing Ets transcription factor (SPDEF) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RBPJ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in immortal lymphoblast cell lines (LCLs) condition			[19]
TF Protein Name	Recombining binding protein suppressor of hairless		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC2A10 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene			[20]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC2A10 gene in . condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[1]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A10 gene in epithelial ovarian cancer condition			[21]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC2A10 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 10.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
MBD3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[2]
TF Protein Name	Methyl-CpG-binding domain protein 3		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Methyl-CpG-binding domain protein 3 (MBD3) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.
REPIN1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A10 gene			[6]
TF Protein Name	Replication initiator 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Replication initiator 1 (REPIN1) can directly bind to the SLC2A10 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 10.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-445. (ID:ENSG00000197496)
4	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
6	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
9	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
10	Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011;12:36.
11	Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
12	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
13	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
14	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
15	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
16	Elevation of transcription factor Islet-1 levels in vivo increases beta-cell function but not beta-cell mass. Islets. 2012 May-Jun;4(3):199-206.
17	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
18	ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
19	Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
20	MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.
21	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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Detail Information of Transcriptional Regulations

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