Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0235 Transporter Info
Gene Name SLC26A7
Transporter Name Anion exchange transporter
Gene ID
115111
UniProt ID
Q8TE54

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC26A7 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC26A7 gene, which in turn affects the expression or function of the drug transporter Anion exchange transporter.

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC26A7 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC26A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC26A7 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A7 gene in prostate cancer condition, which leads to a affected expression of the drug transporter Anion exchange transporter.

       Transcriptional Phenomenon2

 Binding to SLC26A7 gene in prostate cancer condition [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

       Transcriptional Phenomenon3

 Binding to SLC26A7 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

        PPARD 

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       Transcriptional Phenomenon1

 Repression of SLC26A7 gene in myofibroblast condition [6]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC26A7 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Anion exchange transporter.

      Class2.3: C2H2 zinc finger factors

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        KLF5 

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       Transcriptional Phenomenon1

 Activation of SLC26A7 gene in gastric cancer condition [7]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC26A7 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Anion exchange transporter.

        WT1 

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       Transcriptional Phenomenon1

 Activation of SLC26A7 gene in podocyte condition [8]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC26A7 gene in podocyte condition, which leads to an increased expression of the drug transporter Anion exchange transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        PBX1 

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       Transcriptional Phenomenon1

 Activation of SLC26A7 gene in ovarian cancer condition [9]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC26A7 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Anion exchange transporter.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

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       Transcriptional Phenomenon1

 Binding to SLC26A7 gene in prostate cancer condition [10]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC26A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

        FOXM1 

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       Transcriptional Phenomenon1

 Activation of SLC26A7 gene in breast cancer condition [11]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC26A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Anion exchange transporter.

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Binding to SLC26A7 gene in oncogenesis condition [12]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional regulator ERG (ERG) has been reported to bind to the transcription of SLC26A7 gene in oncogenesis condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC26A7 gene in epithelial to mesenchymal transition condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC26A7 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Anion exchange transporter.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Activation of SLC26A7 gene in human embryonic stem cells (hESCs) condition [14]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC26A7 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Anion exchange transporter.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-321. (ID:ENSG00000147606)
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
4 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
5 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
6 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
9 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
10 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
11 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
12 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
13 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
14 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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