Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0152 Transporter Info
Gene Name SLC22A9
Transporter Name Organic anion transporter 7
Gene ID
114571
UniProt ID
Q8IVM8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC22A9 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC22A9 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Organic anion transporter 7.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC22A9 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC22A9 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporter 7.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1A 

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       Transcriptional Phenomenon1

 Activation of SLC22A9 gene in obesity condition [3]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Obesity [ICD11: 5B81]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human obesity liver cell isolates

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC22A9 gene in obesity condition, which leads to an increased expression of the drug transporter Organic anion transporter 7.

      Class3.3: Fork head / winged helix factors

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        FOXA2 

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       Transcriptional Phenomenon1

 Binding to SLC22A9 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC22A9 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporter 7.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC22A9 gene in epithelial ovarian cancer condition [4]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC22A9 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Organic anion transporter 7.
References
1 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
2 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
3 The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1alpha (HNF-1alpha). Mol Pharmacol. 2010 Dec;78(6):1079-87.
4 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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