Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0135 Transporter Info
Gene Name SLC1A7
Transporter Name Excitatory amino acid transporter 5
Gene ID
6512
UniProt ID
O00341

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A7 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC1A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 5.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A7 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC1A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 5.

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [5]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A7 gene in melanoma condition [6]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC1A7 gene in melanoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 5.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene in coronary artery disease context [7]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC1A7 gene in a coronary artery disease context, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A7 gene in glioblastoma multiforme condition [8]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC1A7 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A7 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC1A7 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 5.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A7 gene in erythroleukemia condition [10]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC1A7 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 5.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [5]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [3]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [2]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A7 gene in cancer condition [11]

TF Protein Name

 ETS domain-containing protein Elk-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC1A7 gene in cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 5.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [5]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A7 gene in megakaryocytes condition [12]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC1A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 5.

       Transcriptional Phenomenon2

 Direct binding to SLC1A7 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Stomach; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A7 gene [1]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC1A7 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 5.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
5 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-355. (ID:ENSG00000162383)
6 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
7 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
8 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
9 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
11 The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
12 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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