Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0130 Transporter Info
Gene Name	SLC1A2
Transporter Name	Excitatory amino acid transporter 2
Gene ID	6506
UniProt ID	P43004

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in breast cancer condition			[1]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC1A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in breast cancer condition			[1]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC1A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A2 gene			[2]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC1A2 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 2.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in melanoma condition			[3]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC1A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in embryonic stem cells condition			[4]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC1A2 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
MYCN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A2 gene in astrocytoma condition			[5]
TF Protein Name	N-myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Down regulating
Experimental Material	Human astrocytoma cells (HTB-148)
Detailed Description	N-myc proto-oncogene protein (MYCN) has been reported to repress the transcription of SLC1A2 gene in astrocytoma condition, which leads to a decreased expression of the drug transporter Excitatory amino acid transporter 2.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in glioblastoma multiforme condition			[6]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC1A2 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in MCF7 cells			[7]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC1A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene			[8]
TF Protein Name	Androgen receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC1A2 gene in . condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC1A2 gene in prostate cancer condition			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC1A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in health condition			[10]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC1A2 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
NR3C1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in health condition			[11]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Affected Drug/Substrate	Glutamate
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Rats astrocyte isolates
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC1A2 gene in health condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A2 gene in health condition			[12]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	down regulating
Experimental Material	YY1-loxP homozygous mice astrocytes
Detailed Description	Transcriptional repressor protein YY1 (YY1), influenced by the exogenous manganese chloride, has been reported to repress the transcription of SLC1A2 gene in health condition , which leads to a decreased expression of the drug transporter Excitatory amino acid transporter 2.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in breast cancer condition			[13]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC1A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
TF Superclass3: Helix-turn-helix domains
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in MCF7 cells			[7]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC1A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC1A2 gene in MCF7 condition			[14]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC1A2 gene in MCF7 condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A2 gene			[15]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC1A2 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 2.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in health condition			[10]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC1A2 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A2 gene			[16]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC1A2 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 2.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in breast cancer condition			[17]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC1A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in health condition			[18]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Interferon regulatory factor 1 (IRF1) has been reported to activate the transcription of SLC1A2 gene in health condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A2 gene			[19]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC1A2 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 2.
NFKB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in astrocytoma condition			[5]
TF Protein Name	Nuclear factor NF-kappa-B p105 subunit		Transcription Factor Info
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human astrocytoma cells (HTB-148)
Detailed Description	Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to activate the transcription of SLC1A2 gene in astrocytoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in astrocytoma condition			[5]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human astrocytoma cells (HTB-148)
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of SLC1A2 gene in astrocytoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A2 gene			[20]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC1A2 gene in . condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A2 gene in atherosclerosis condition			[21]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to activate the transcription of SLC1A2 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 2.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A2 gene in health condition			[22]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC1A2 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 2.

References
1	High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-210. (ID:ENSG00000110436)
3	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
4	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
5	Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. EMBO J. 2005 Feb 9;24(3):510-20.
6	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
8	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
9	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
10	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
11	Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions. J Biol Chem. 2005 Oct 14;280(41):34924-32.
12	Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 Nov 13;295(46):15662-15676.
13	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
14	Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
15	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
16	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
17	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
18	A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response. Nucleic Acids Res. 2009;37(4):1073-85.
19	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
20	MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.
21	p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62.
22	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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Detail Information of Transcriptional Regulations

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