Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0129 Transporter Info
Gene Name SLC1A1
Transporter Name Excitatory amino acid transporter 3
Gene ID
6505
UniProt ID
P43005

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

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       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

      Class1.2: Basic helix-loop-helix factors

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        EPAS1 

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       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in hepatocellular carcinoma condition [2]

TF Protein Name

 Endothelial PAS domain-containing protein 1 Transcription Factor Info

Affected Drug/Substrate

 Glutamate

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human childhood hepatocellular carcinoma cells (Hep3B)

Detailed Description

 Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC1A1 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

        HIF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in hepatocellular carcinoma condition [2]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Affected Drug/Substrate

 Glutamate

Studied Phenotype

 Hepatocellular carcinoma [ICD11: 2C12.02]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human childhood hepatocellular carcinoma cells (Hep3B)

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC1A1 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

      Class1.3: Basic helix-span-helix factors

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        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [3]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A1 gene in prostate cancer condition [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC1A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 3.

       Transcriptional Phenomenon2

 Direct binding to SLC1A1 gene [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC1A1 gene in . condition, which leads to a affected expression of the drug transporter Excitatory amino acid transporter 3.

       Transcriptional Phenomenon3

 Binding to SLC1A1 gene in prostate cancer condition [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC1A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 3.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in ER(-) breast cancer condition [7]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC1A1 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

      Class2.3: C2H2 zinc finger factors

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        GLIS1 

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       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [1]

TF Protein Name

 Zinc finger protein GLIS1 Transcription Factor Info

Tissue

 Blood; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein GLIS1 (GLIS1) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in renal cysts condition [8]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC1A1 gene in renal cysts condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

        NANOG 

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       Transcriptional Phenomenon1

 Binding to SLC1A1 gene in health condition [9]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC1A1 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 3.

      Class3.3: Fork head / winged helix factors

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        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [10]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

        FOXO3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in tumorigenesis condition [11]

TF Protein Name

 Forkhead box protein O3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC1A1 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

        RFX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in brain neuroblastoma condition [12]

TF Protein Name

 MHC class II regulatory factor RFX1 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Human neuroblastoma cells (SH-SY5Y)

Detailed Description

 MHC class II regulatory factor RFX1 (RFX1) has been reported to activate the transcription of SLC1A1 gene in brain neuroblastoma condition, which leads to an enhanced function of the drug transporter Excitatory amino acid transporter 3.

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [13]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC1A1 gene in acute promyelocytic leukemia condition [14]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC1A1 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 3.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

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        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in colorectal cancer condition [15]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC1A1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC1A1 gene [3]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC1A1 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 3.

      Class6.4: Runt domain factors

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        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in prostate cancer condition [16]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC1A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in hESCs condition [17]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC1A1 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

        SMAD4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC1A1 gene in epithelial ovarian cancer condition [18]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC1A1 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.

       Transcriptional Phenomenon2

 Activation of SLC1A1 gene in hESCs condition [17]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC1A1 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 3.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014 Oct 15;5(19):8853-68.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-203. (ID:ENSG00000106688)
4 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
5 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
6 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
7 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
8 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
9 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
10 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
11 Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
12 The transcription factor regulatory factor X1 increases the expression of neuronal glutamate transporter type 3. J Biol Chem. 2006 Jul 28;281(30):21250-21255.
13 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
14 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
15 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
16 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
17 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
18 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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