Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0116 Transporter Info
Gene Name SLC17A3
Transporter Name Sodium-dependent phosphate transport protein 4
Gene ID
10786
UniProt ID
O00476

Transcriptional Regulation of This DT (TSR)

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC17A3 gene in health condition [1]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC17A3 gene in health condition, which leads to an affected expression of the drug transporter Sodium-dependent phosphate transport protein 4.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC17A3 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 129Sv-C57BL6/J hybrid mice

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC17A3 gene in health condition, which leads to an increased expression of the drug transporter Sodium-dependent phosphate transport protein 4.
References
1 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
2 Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. J Mol Biol. 2002 Oct 4;322(5):929-41.

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