Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0103 Transporter Info
Gene Name SLC16A12
Transporter Name Monocarboxylate transporter 12
Gene ID
387700
UniProt ID
Q6ZSM3

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC16A12 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC16A12 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 12.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A12 gene [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC16A12 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 12.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A12 gene in K562 cells [3]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC16A12 gene in K562 cells, which leads to an affected expression of the drug transporter Monocarboxylate transporter 12.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        NR3C1 

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       Transcriptional Phenomenon1

 Activation of SLC16A12 gene in health condition [4]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Bronchus

Related DT Changes

 Up regulating

Experimental Material

 human bronchial epithelial cell isolates

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC16A12 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 12.

      Class2.3: C2H2 zinc finger factors

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        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A12 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A12 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 12.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A12 gene in health condition [6]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of SLC16A12 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 12.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A12 gene [7]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC16A12 gene in . condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 12.
References
1 In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-331. (ID:ENSG00000152779)
3 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
4 Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells. BMC Med Genomics. 2019 Jan 31;12(1):29.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
7 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.

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