Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0095 Transporter Info
Gene Name SLC13A5
Transporter Name Sodium-coupled citrate transporter
Gene ID
284111
UniProt ID
Q86YT5

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

      Class1.2: Basic helix-loop-helix factors

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        AHR 

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       Transcriptional Phenomenon1

 Activation of SLC13A5 gene in health condition [2]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 Citrate

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Wistar rats

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC13A5 gene in health condition, which leads to an increased expression of the drug transporter Sodium-coupled citrate transporter.

        TCF3 

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       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [3]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

      Class1.3: Basic helix-span-helix factors

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        TFAP2A 

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       Transcriptional Phenomenon1

 Binding to SLC13A5 gene in MCF7 cells [4]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC13A5 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-coupled citrate transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC13A5 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC13A5 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled citrate transporter.

        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC13A5 gene in health condition [6]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC13A5 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled citrate transporter.

        NR1I2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC13A5 gene in health condition [7]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 human primary hepatocyte isolates

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of SLC13A5 gene in health condition, which leads to an increased expression of the drug transporter Sodium-coupled citrate transporter.

      Class2.3: C2H2 zinc finger factors

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        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F6 

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       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [8]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

      Class3.5: Tryptophan cluster factors

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        GABPA 

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       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [9]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC13A5 gene [1]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC13A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled citrate transporter.

TF Superclass6: Immunoglobulin fold

      Class6.5: T-Box factors

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        EOMES 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC13A5 gene in health condition [10]

TF Protein Name

 Eomesodermin homolog Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Eomesodermin homolog (EOMES) has been reported to activate the transcription of SLC13A5 gene in health condition, which leads to an increased expression of the drug transporter Sodium-coupled citrate transporter.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-300. (ID:ENSG00000141485)
2 Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes. Toxicology. 2015 Nov 4;337:1-9.
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
6 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
7 Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes. Cells. 2021 Dec 1;10(12):3381.
8 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
9 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
10 Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.

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