Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0053 Transporter Info
Gene Name ABCB7
Transporter Name ABC transporter 7 protein
Gene ID
22
UniProt ID
O75027

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NR1I2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB7 gene in health condition [4]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 up regulating

Experimental Material

 Human liver samples

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous carbamazepine, has been reported to activate the transcription of ABCB7 gene in health condition , which leads to an increased expression of the drug transporter ABC transporter 7 protein.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [1]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [2]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCB7 gene in multiple human cancer types condition [5]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ABCB7 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter ABC transporter 7 protein.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB7 gene in health condition [6]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of ABCB7 gene in health condition, which leads to an affected expression of the drug transporter ABC transporter 7 protein.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [7]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [7]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Brain; Breast; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCB7 gene [2]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the ABCB7 gene, which in turn affects the expression or function of the drug transporter ABC transporter 7 protein.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB7 gene in acute promyelocytic leukemia condition [8]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCB7 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter ABC transporter 7 protein.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCB7 gene in health condition [6]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of ABCB7 gene in health condition, which leads to an affected expression of the drug transporter ABC transporter 7 protein.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-263. (ID:ENSG00000131269)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
5 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
6 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.

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