Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0042 Transporter Info
Gene Name ABCA4
Transporter Name ATP-binding cassette sub-family A member 4
Gene ID
24
UniProt ID
P78363

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [1]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Breast; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Brain; Cervix; Colon; Coronary artery; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        mutated HLF (c.761A>T) 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in stargardt disease condition [3]

TF Protein Name

 Hepatic leukemia factor Transcription Factor Info

Studied Phenotype

 Stargardt disease [ICD11: 9B70]

Tissue

 Eye

Related DT Changes

 Up regulating

Experimental Material

 human Stargardt disease cell isolates

Detailed Description

 mutated Hepatic leukemia factor (mutated HLF (c.761A>T)) has been reported to activate the transcription of ABCA4 gene in stargardt disease condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCA4 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in breast cancer condition [4]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of ABCA4 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in melanoma condition [5]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ABCA4 gene in melanoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in colorectal cancer condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of ABCA4 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in prostate cancer condition [7]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of ABCA4 gene in prostate cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [8]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCA4 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

        NR1H3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in atherosclerotic foam cells condition [10]

TF Protein Name

 Oxysterols receptor LXR-alpha Transcription Factor Info

Affected Drug/Substrate

 T0901317

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA4 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in health condition [11]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of ABCA4 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

        GATA3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in breast cancer condition [12]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ABCA4 gene in breast cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

       Transcriptional Phenomenon2

 Direct binding to ABCA4 gene [13]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood; Brain; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        mutated GATA2 (c.761C>A) 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in stargardt disease condition [3]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 Stargardt disease [ICD11: 9B70]

Tissue

 Eye

Related DT Changes

 Up regulating

Experimental Material

 human Stargardt disease cell isolates

Detailed Description

 mutated Endothelial transcription factor GATA-2 (mutated GATA2 (c.761C>A)) has been reported to activate the transcription of ABCA4 gene in stargardt disease condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in gastric cancer condition [14]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of ABCA4 gene in gastric cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in podocyte condition [15]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of ABCA4 gene in podocyte condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [8]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [13]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in megakaryocytes condition [16]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ABCA4 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

       Transcriptional Phenomenon2

 Direct binding to ABCA4 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to ABCA4 gene [1]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ABCA4 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 4.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in epithelial to mesenchymal transition condition [17]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCA4 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

       Transcriptional Phenomenon2

 Binding to ABCA4 gene in health condition [18]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCA4 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCA4 gene in prostate cancer condition [19]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCA4 gene in prostate cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 4.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCA4 gene in epithelial ovarian cancer condition [20]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of ABCA4 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 4.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-450. (ID:ENSG00000198691)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Functional characterization of ABCA4 genetic variants related to Stargardt disease. Sci Rep. 2022 Dec 24;12(1):22282.
4 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
5 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6 Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
7 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
8 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
9 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10 Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
11 Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011;30(13):2582-95.
12 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
13 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
14 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
15 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
16 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
17 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
18 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
19 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
20 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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