Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0027 Transporter Info
Gene Name SLC22A12
Transporter Name Urate anion exchanger 1
Gene ID
116085
UniProt ID
Q96S37

Transcriptional Regulation of This DT (TSR)

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        ESR1 

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       Transcriptional Phenomenon1

 Activation of SLC22A12 gene in hepatoblastoma condition [1]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Affected Drug/Substrate

 Uric acid

Studied Phenotype

 Hepatoblastoma [ICD11: 2C12.01]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human hepatoblastoma cells (HepG2)

Detailed Description

 Estrogen receptor (ESR1) has been reported to activate the transcription of SLC22A12 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Urate anion exchanger 1.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC22A12 gene in erythroleukemia condition [2]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC22A12 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Urate anion exchanger 1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1A 

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       Transcriptional Phenomenon1

 Activation of SLC22A12 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Hnf1a KO mice

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC22A12 gene in health condition, which leads to an increased expression of the drug transporter Urate anion exchanger 1.

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC22A12 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Hnf1a KO mice

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC22A12 gene in health condition, which leads to an increased expression of the drug transporter Urate anion exchanger 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC22A12 gene in epithelial ovarian cancer condition [4]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC22A12 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Urate anion exchanger 1.
References
1 27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. FASEB J. 2021 Jan;35(1):e21262.
2 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
3 Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. Mol Pharmacol. 2007 Dec;72(6):1619-25.
4 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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