Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0024 Transporter Info
Gene Name SLC22A6
Transporter Name Organic anion transporter 1
Gene ID
9356
UniProt ID
Q4U2R8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        AHR 

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       Transcriptional Phenomenon1

 Activation of SLC22A6 gene in health condition [1]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR), influenced by the indole metabolite from Host unspecified microbiota, has been reported to activate the transcription of SLC22A6 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Activation of SLC22A6 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 North american opossum Kidney cells (OK)

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to activate the transcription of SLC22A6 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporter 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC22A6 gene in epithelial ovarian cancer condition [3]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC22A6 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Organic anion transporter 1.
References
1 Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16105-16110.
2 Hepatocyte nuclear factor-4{alpha} regulates the human organic anion transporter 1 gene in the kidney. Am J Physiol Renal Physiol. 2007 Jun;292(6):F1819-26.
3 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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