Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0022 Transporter Info
Gene Name SLC15A2
Transporter Name Peptide transporter 2
Gene ID
6565
UniProt ID
Q16348

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

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       Transcriptional Phenomenon1

 Direct binding to SLC15A2 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC15A2 gene, which in turn affects the expression or function of the drug transporter Peptide transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Direct binding to SLC15A2 gene [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Tissue

 Breast; Cervix; Kidney; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Androgen receptor (AR) can directly bind to the SLC15A2 gene, which in turn affects the expression or function of the drug transporter Peptide transporter 2.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC15A2 gene in myofibroblasts condition [3]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC15A2 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Peptide transporter 2.

      Class2.2: Other C4 zinc finger-type factors

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        GATA6 

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       Transcriptional Phenomenon1

 Activation of SLC15A2 gene in gastric cancer condition [4]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC15A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Peptide transporter 2.

      Class2.3: C2H2 zinc finger factors

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        BCL6 

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       Transcriptional Phenomenon1

 Activation of SLC15A2 gene in health condition [5]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC15A2 gene in health condition, which leads to an increased expression of the drug transporter Peptide transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1B 

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       Transcriptional Phenomenon1

 Activation of SLC15A2 gene in renal cysts condition [6]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC15A2 gene in renal cysts condition, which leads to an increased expression of the drug transporter Peptide transporter 2.

        NANOG 

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       Transcriptional Phenomenon1

 Binding to SLC15A2 gene in HESC condition [7]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC15A2 gene in HESC condition, which leads to an affected expression of the drug transporter Peptide transporter 2.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC15A2 gene in prostate cancer condition [8]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC15A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Peptide transporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC15A2 gene [9]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC15A2 gene, which in turn affects the expression or function of the drug transporter Peptide transporter 2.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

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        SOX2 

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       Transcriptional Phenomenon1

 Binding to SLC15A2 gene in health condition [7]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC15A2 gene in health condition, which leads to an affected expression of the drug transporter Peptide transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT1 

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       Transcriptional Phenomenon1

 Direct binding to SLC15A2 gene [10]

TF Protein Name

 Signal transducer and activator of transcription 1-alpha/beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC15A2 gene in . condition, which leads to an affected expression of the drug transporter Peptide transporter 2.

      Class6.7: Grainyhead domain factors

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        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC15A2 gene [11]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC15A2 gene, which in turn affects the expression or function of the drug transporter Peptide transporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-359. (ID:ENSG00000163406)
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
4 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
5 The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
6 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
7 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
8 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
9 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
10 MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.
11 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.

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