Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0008 Transporter Info
Gene Name SLCO1B1
Transporter Name Organic anion transporting polypeptide 1B1
Gene ID
10599
UniProt ID
Q9Y6L6

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B1 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLCO1B1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B1.

      Class1.2: Basic helix-loop-helix factors

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        AHR 

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       Transcriptional Phenomenon1

 Repression of SLCO1B1 gene in health condition [2]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Down regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to repress the transcription of SLCO1B1 gene in health condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 1B1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1B1 gene in glioblastoma multiforme condition [3]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLCO1B1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1B1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        NR1I2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B1 gene in cholestatic liver disease condition [4]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Cholestatic liver disease [ICD11: DB99]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of SLCO1B1 gene in cholestatic liver disease condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B1.

       Transcriptional Phenomenon2

 Activation of SLCO1B1 gene in health condition [5]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 129/SvJ mice

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of SLCO1B1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B1.

        NR1I3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B1 gene in health condition [2]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 3 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Nuclear receptor subfamily 1 group I member 3 (NR1I3) has been reported to activate the transcription of SLCO1B1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1B1 gene in prostate cancer condition [6]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLCO1B1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1B1.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. J Pharmacol Exp Ther. 2002 Jan;300(1):206-12.
3 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
4 The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther. 2005 Feb;312(2):841-8.
5 Regulation of drug transporter gene expression by nuclear receptors. Drug Metab Dispos. 2003 May;31(5):523-7.
6 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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