Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0002 Transporter Info
Gene Name	ABCC2
Transporter Name	Multidrug resistance-associated protein 2
Gene ID	1244
UniProt ID	Q92887

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCC2 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in coronary artery disease condition			[2]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the ABCC2 gene in coronary artery disease condition, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in coronary artery disease condition			[2]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of ABCC2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 2.
NFE2L2		Click to Show/Hide to Show 5 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in health condition			[3]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Affected Drug/Substrate	Arsenic
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatocytes
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous arsenic, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon2	Activation of ABCC2 gene in hepatoblastoma condition			[4]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of ABCC2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon3	Activation of ABCC2 gene in health condition			[5]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	C57/B6 mice
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous arsenic, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon4	Activation of ABCC2 gene in brain neuroblastoma condition			[6]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Brain neuroblastoma [ICD11: 2A00.11]
Tissue	Brain
Related DT Changes	up regulating
Experimental Material	Human neuroblastoma cells (SH-SY5Y)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous arsenic, has been reported to activate the transcription of ABCC2 gene in brain neuroblastoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon5	Activation of ABCC2 gene in health condition			[7]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of ABCC2 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in health condition			[7]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCC2 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in melanoma condition			[8]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ABCC2 gene in melanoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene in coronary artery disease condition			[2]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the ABCC2 gene in coronary artery disease condition, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in prostate cancer condition			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCC2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 2.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC2 gene in breast cancer condition			[10]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	down regulating
Experimental Material	Human breast carcinoma cells (MCF-7)
Detailed Description	Estrogen receptor (ESR1), influenced by the exogenous fulvestrant, has been reported to repress the transcription of ABCC2 gene in breast cancer condition , which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 2.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene			[11]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the ABCC2 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
NR1H4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in hepatoblastoma condition			[12]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Bile acid receptor (NR1H4) has been reported to activate the transcription of ABCC2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon2	Activation of ABCC2 gene in health condition			[13]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Male mice
Detailed Description	Bile acid receptor (NR1H4), influenced by the exogenous lithocholic acid, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
NR1I2		Click to Show/Hide to Show 6 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in hepatoblastoma condition			[12]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of ABCC2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon2	Activation of ABCC2 gene in cholestatic liver disease condition			[14]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Cholestatic liver disease [ICD11: DB99]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of ABCC2 gene in cholestatic liver disease condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon3	Activation of ABCC2 gene in health condition			[15]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous resveratrol, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon4	Activation of ABCC2 gene in hepatocellular carcinoma condition			[16]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatocellular carcinoma (HepaRG)
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous resveratrol, has been reported to activate the transcription of ABCC2 gene in hepatocellular carcinoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon5	Activation of ABCC2 gene in bile duct obstruction condition			[17]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Bile duct obstruction [DC10.02]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Wistar rats
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous resveratrol, has been reported to activate the transcription of ABCC2 gene in bile duct obstruction condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon6	Activation of ABCC2 gene in health condition			[18]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Duodenum
Related DT Changes	up regulating
Experimental Material	Human duodenal mucosa biopsy specimens
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous resveratrol, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
NR1I3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in hepatoblastoma condition			[19]
TF Protein Name	Nuclear receptor subfamily 1 group I member 3		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Nuclear receptor subfamily 1 group I member 3 (NR1I3) has been reported to activate the transcription of ABCC2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Transcriptional Phenomenon2	Activation of ABCC2 gene in health condition			[7]
TF Protein Name	Nuclear receptor subfamily 1 group I member 3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 3 (NR1I3) has been reported to activate the transcription of ABCC2 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
PPARA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in health condition			[20]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	up regulating
Experimental Material	Sprague Dawley rats
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA), influenced by the exogenous perfluorooctane sulfonic acid, has been reported to activate the transcription of ABCC2 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in breast cancer condition			[21]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ABCC2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 2.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in gastric cancer condition			[22]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of ABCC2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in gastric cancer condition			[22]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of ABCC2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
HNF1A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in sepsis condition			[23]
TF Protein Name	Hepatocyte nuclear factor 1-alpha		Transcription Factor Info
Studied Phenotype	Sepsis [ICD11: 1G40-1G41]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of ABCC2 gene in sepsis condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
ONECUT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in health condition			[24]
TF Protein Name	Hepatocyte nuclear factor 6		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Mouse liver hepatic sinusoidal endothelial cells (SV40LG)
Detailed Description	Hepatocyte nuclear factor 6 (ONECUT1) has been reported to activate the transcription of ABCC2 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene			[25]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCC2 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in health condition			[11]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ABCC2 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
IRF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC2 gene in hepatoblastoma condition			[26]
TF Protein Name	Interferon regulatory factor 3		Transcription Factor Info
Affected Drug/Substrate	Actinomycin D
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Interferon regulatory factor 3 (IRF3) has been reported to activate the transcription of ABCC2 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 2.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene			[27]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCC2 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC2 gene in health condition			[28]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCC2 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 2.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC2 gene			[29]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the ABCC2 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 2.

References
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2	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3	Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes. Toxicol Sci. 2015 Jun;145(2):307-20.
4	Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol. 2007;6(4):335-48.
5	Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47.
6	Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010 Aug 20;285(34):26190-8.
7	Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos. 2005 Jul;33(7):956-62.
8	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
9	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
10	Fulvestrant up regulates UGT1A4 and MRPs through ERalpha and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620.
11	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
12	Hepatobiliary transport of bile acids and organic anions. J Hepatobiliary Pancreat Surg. 2002;9(4):443-7.
13	Preventive effect of Juniperus procera extract on liver injury induced by lithocholic acid. Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):63-68.
14	The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther. 2005 Feb;312(2):841-8.
15	Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. Br J Pharmacol. 2007 Jun;151(3):367-76.
16	Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. Hepatology. 2013 May;57(5):1931-41.
17	Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692.
18	Transcriptional and Post-Transcriptional Regulation of Duodenal P-Glycoprotein and MRP2 in Healthy Human Subjects after Chronic Treatment with Rifampin and Carbamazepine. Mol Pharm. 2019 Sep 3;16(9):3823-3830.
19	Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15.
20	PPAR-alpha, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression. J Cereb Blood Flow Metab. 2017 Apr;37(4):1199-1212.
21	Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
22	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
23	IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters. Shock. 2008 Apr;29(4):490-6.
24	Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G769-77.
25	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
26	Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells. Hepatology. 2004 Jun;39(6):1574-82.
27	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
28	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
29	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801

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Detail Information of Transcriptional Regulations

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