Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0533 Transporter Info
Gene Name	ATP7B
Transporter Name	Copper-transporting ATPase 2
Gene ID	540
UniProt ID	P35670

Post-Translational Modification of This DT
Overview ofATP7B Modification Sites with Functional and Structural Information
Sequence	M P E Q E R Q I T A R E G A S R K I L S K L S L P T R A W E P A M K K S F A F D N V G Y E G G L D G L G P S S Q V A T S T V R I L G M T C Q S C V K S I E D R I S N L K G I I S M K V S L E Q G S A T V K Y V P S V V C L Q Q V C H Q I G D M G F E A S I A E G K A A S W P S R S L P A Q E A V V K L R V E G M T C Q S C V S S I E G K V R K L Q G V V R V K V S L S N Q E A V I T Y Q P Y L I Q P E D L R D H V N D M G F E A A I K S K V A P L S L G P I D I E R L Q S T N P K R P L S S A N Q N F N N S E T L G H Q G S H V V T L Q L R I D G M H C K S C V L N I E E N I G Q L L G V Q S I Q V S L E N K T A Q V K Y D P S C T S P V A L Q R A I E A L P P G N F K V S L P D G A E G S G T D H R S S S S H S P G S P P R N Q V Q G T C S T T L I A I A G M T C A S C V H S I E G M I S Q L E G V Q Q I S V S L A E G T A T V L Y N P S V I S P E E L R A A I E D M G F E A S V V S E S C S T N P L G N H S A G N S M V Q T T D G T P T S V Q E V A P H T G R L P A N H A P D I L A K S P Q S T R A V A P Q K C F L Q I K G M T C A S C V S N I E R N L Q K E A G V L S V L V A L M A G K A E I K Y D P E V I Q P L E I A Q F I Q D L G F E A A V M E D Y A G S D G N I E L T I T G M T C A S C V H N I E S K L T R T N G I T Y A S V A L A T S K A L V K F D P E I I G P R D I I K I I E E I G F H A S L A Q R N P N A H H L D H K M E I K Q W K K S F L C S L V F G I P V M A L M I Y M L I P S N E P H Q S M V L D H N I I P G L S I L N L I F F I L C T F V Q L L G G W Y F Y V Q A Y K S L R H R S A N M D V L I V L A T S I A Y V Y S L V I L V V A V A E K A E R S P V T F F D T P P M L F V F I A L G R W L E H L A K S K T S E A L A K L M S L Q A T E A T V V T L G E D N L I I R E E Q V P M E L V Q R G D I V K V V P G G K F P V D G K V L E G N T M A D E S L I T G E A M P V T K K P G S T V I A G S I N A H G S V L I K A T H V G N D T T L A Q I V K L V E E A Q M S K A P I Q Q L A D R F S G Y F V P F I I I M S T L T L V V W I V I G F I D F G V V Q R Y F P N P N K H I S Q T E V I I R F A F Q T S I T V L C I A C P C S L G L A T P T A V M V G T G V A A Q N G I L I K G G K P L E M A H K I K T V M F D K T G T I T H G V P R V M R V L L L G D V A T L P L R K V L A V V G T A E A S S E H P L G V A V T K Y C K E E L G T E T L G Y C T D F Q A V P G C G I G C K V S N V E G I L A H S E R P L S A P A S H L N E A G S L P A E K D A V P Q T F S V L I G N R E W L R R N G L T I S S D V S D A M T D H E M K G Q T A I L V A I D G V L C G M I A I A D A V K Q E A A L A V H T L Q S M G V D V V L I T G D N R K T A R A I A T Q V G I N K V F A E V L P S H K V A K V Q E L Q N K G K K V A M V G D G V N D S P A L A Q A D M G V A I G T G T D V A I E A A D V V L I R N D L L D V V A S I H L S K R T V R R I R I N L V L A L I Y N L V G I P I A A G V F M P I G I V L Q P W M G S A A M A A S S V S V V L S S L Q L K C Y K K P D L E R Y E A Q A H G H M K P L T A S Q V S V H I G M D D R W R D S P R A T P W D Q V S Y V S Q V S L S S L T S D K P S R H S A A A D D D G D K W S L L L N G R D E E Q Y I
PTM type	X-Acetylation X-Acetylation X-O-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	785
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ATP7B Lysine 785 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	794
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ATP7B Lysine 794 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ATP7B			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1028
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ATP7B Lysine 1028 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ATP7B			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1258
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ATP7B Lysine 1258 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ATP7B			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1260
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ATP7B Lysine 1260 has the potential to affect its expression or activity.
O-glycosylation
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	788
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ATP7B Threonine 788 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	268
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ATP7B Cystine 268 has the potential to affect its expression or activity.
Phosphorylation
Serine	39 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[8]
Role of PTM	Potential impacts
Affected Drug/Substrate	Copper	Results for Drug	Affecting the inward transport of copper
Modified Residue	Serine
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ATP7B			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	20
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 20 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ATP7B			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	23
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 23 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 81 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ATP7B			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	132
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 132 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ATP7B			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	135
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 135 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ATP7B			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ATP7B			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	177
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 177 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ATP7B			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	179
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 179 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ATP7B			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	218
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 218 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ATP7B			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	304
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 304 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ATP7B			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	307
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 307 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ATP7B			[12], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	340
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 340 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ATP7B			[12], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	341
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 341 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ATP7B			[12], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 342 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ATP7B			[12], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	343
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 343 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ATP7B			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	345
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 345 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ATP7B			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	348
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 348 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ATP7B			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	478
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 478 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ATP7B			[9], [22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 481 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ATP7B			[23]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 596 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ATP7B			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	876
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 876 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence ATP7B			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	882
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 882 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence ATP7B			[25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1066
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1066 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence ATP7B			[26], [27]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1121 has the potential to affect its expression or activity.
PTM Phenomenon26	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1145
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1145 has the potential to affect its expression or activity.
PTM Phenomenon27	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1163
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1163 has the potential to affect its expression or activity.
PTM Phenomenon28	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1211
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1211 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence ATP7B			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1310 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence ATP7B			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1314
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1314 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence ATP7B			[12], [29]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1398
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1398 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence ATP7B			[12], [29]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1401 has the potential to affect its expression or activity.
PTM Phenomenon33	.			[30]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1413
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1413 has the potential to affect its expression or activity.
PTM Phenomenon34	.			[30]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1413
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1413 has the potential to affect its expression or activity.
PTM Phenomenon35	.			[30]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1413
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1413 has the potential to affect its expression or activity.
PTM Phenomenon36	Have the potential to influence ATP7B			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1426
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1426 has the potential to affect its expression or activity.
PTM Phenomenon37	Have the potential to influence ATP7B			[12], [31]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1429
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1429 has the potential to affect its expression or activity.
PTM Phenomenon38	Have the potential to influence ATP7B			[32]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1442
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1442 has the potential to affect its expression or activity.
PTM Phenomenon39	Have the potential to influence ATP7B			[12], [31]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1453
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Serine 1453 has the potential to affect its expression or activity.
Threonine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 26 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ATP7B			[15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	186
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 186 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ATP7B			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	306
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 306 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ATP7B			[9], [22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 482 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ATP7B			[33]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	587
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 587 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ATP7B			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	589
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 589 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ATP7B			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	593
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 593 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1050
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 1050 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1076
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 1076 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1143
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 1143 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1208
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 1208 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1220
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Threonine 1220 has the potential to affect its expression or activity.
Tyrosine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[34]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	44
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 44 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ATP7B			[15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	187
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 187 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ATP7B			[15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 190 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ATP7B			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	301
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 301 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ATP7B			[23]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	594
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 594 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ATP7B			[25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1078
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 1078 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ATP7B			[34]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1424
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ATP7B Tyrosine 1424 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ATP7B			[35]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ATP7B Lysine 489 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ATP7B			[35]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	607
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ATP7B Lysine 607 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ATP7B			[35]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1028
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ATP7B Lysine 1028 has the potential to affect its expression or activity.

References
1	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
2	Partial trisomy 3q due to a de novo translocation t(X;3) (p21;q12). Clin Genet. 1981 Aug;20(2):130-4.
3	Linkage analysis of late-infantile neuronal ceroid-lipofuscinosis. Am J Med Genet. 1995 Jun 5;57(2):348-9.
4	Biotin-labeled potato chymotrypsin inhibitor-1: a useful probe for the detection and quantitation of chymotrypsin-like serine proteinases on western blots and its application in the detection of a serine proteinase synthesised by articular chondrocytes. Anal Biochem. 1995 May 1;227(1):129-34.
5	Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag). Mol Cell Proteomics. 2018 Apr;17(4):764-775.
6	A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry. Chem Commun (Camb). 2018 Dec 6;54(98):13790-13793.
7	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
8	Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes. J Med Genet. 2007 Nov;44(11):673-88.
9	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
10	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
11	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
12	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
13	Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 May;17(5):836-849.
14	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
15	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
16	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
17	Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Sci Rep. 2017 Dec 5;7(1):17024.
18	Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27.
19	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
20	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
21	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
22	Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71.
23	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
24	Phosphoproteomics study on the activated PKC-induced cell death. J Proteome Res. 2013 Oct 4;12(10):4280-301.
25	Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6.
26	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
27	Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem. 2011 Mar 4;286(9):7389-96.
28	Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis. J Proteome Res. 2015 Sep 4;14(9):4087-98.
29	Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst. 2016 Mar 23;2(3):159-71.
30	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
31	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
32	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
33	Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib. J Proteomics. 2018 Jan 6;170:130-140.
34	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
35	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.

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