Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0526 Transporter Info
Gene Name	SCN1A
Transporter Name	Voltage-gated sodium channel alpha Nav1.1
Gene ID	6323
UniProt ID	P35498

Post-Translational Modification of This DT
Overview ofSCN1A Modification Sites with Functional and Structural Information
Sequence	M E Q T V L V P P G P D S F N F F T R E S L A A I E R R I A E E K A K N P K P D K K D D D E N G P K P N S D L E A G K N L P F I Y G D I P P E M V S E P L E D L D P Y Y I N K K T F I V L N K G K A I F R F S A T S A L Y I L T P F N P L R K I A I K I L V H S L F S M L I M C T I L T N C V F M T M S N P P D W T K N V E Y T F T G I Y T F E S L I K I I A R G F C L E D F T F L R D P W N W L D F T V I T F A Y V T E F V D L G N V S A L R T F R V L R A L K T I S V I P G L K T I V G A L I Q S V K K L S D V M I L T V F C L S V F A L I G L Q L F M G N L R N K C I Q W P P T N A S L E E H S I E K N I T V N Y N G T L I N E T V F E F D W K S Y I Q D S R Y H Y F L E G F L D A L L C G N S S D A G Q C P E G Y M C V K A G R N P N Y G Y T S F D T F S W A F L S L F R L M T Q D F W E N L Y Q L T L R A A G K T Y M I F F V L V I F L G S F Y L I N L I L A V V A M A Y E E Q N Q A T L E E A E Q K E A E F Q Q M I E Q L K K Q Q E A A Q Q A A T A T A S E H S R E P S A A G R L S D S S S E A S K L S S K S A K E R R N R R K K R K Q K E Q S G G E E K D E D E F Q K S E S E D S I R R K G F R F S I E G N R L T Y E K R Y S S P H Q S L L S I R G S L F S P R R N S R T S L F S F R G R A K D V G S E N D F A D D E H S T F E D N E S R R D S L F V P R R H G E R R N S N L S Q T S R S S R M L A V F P A N G K M H S T V D C N G V V S L V G G P S V P T S P V G Q L L P E V I I D K P A T D D N G T T T E T E M R K R R S S S F H V S M D F L E D P S Q R Q R A M S I A S I L T N T V E E L E E S R Q K C P P C W Y K F S N I F L I W D C S P Y W L K V K H V V N L V V M D P F V D L A I T I C I V L N T L F M A M E H Y P M T D H F N N V L T V G N L V F T G I F T A E M F L K I I A M D P Y Y Y F Q E G W N I F D G F I V T L S L V E L G L A N V E G L S V L R S F R L L R V F K L A K S W P T L N M L I K I I G N S V G A L G N L T L V L A I I V F I F A V V G M Q L F G K S Y K D C V C K I A S D C Q L P R W H M N D F F H S F L I V F R V L C G E W I E T M W D C M E V A G Q A M C L T V F M M V M V I G N L V V L N L F L A L L L S S F S A D N L A A T D D D N E M N N L Q I A V D R M H K G V A Y V K R K I Y E F I Q Q S F I R K Q K I L D E I K P L D D L N N K K D S C M S N H T A E I G K D L D Y L K D V N G T T S G I G T G S S V E K Y I I D E S D Y M S F I N N P S L T V T V P I A V G E S D F E N L N T E D F S S E S D L E E S K E K L N E S S S S S E G S T V D I G A P V E E Q P V V E P E E T L E P E A C F T E G C V Q R F K C C Q I N V E E G R G K Q W W N L R R T C F R I V E H N W F E T F I V F M I L L S S G A L A F E D I Y I D Q R K T I K T M L E Y A D K V F T Y I F I L E M L L K W V A Y G Y Q T Y F T N A W C W L D F L I V D V S L V S L T A N A L G Y S E L G A I K S L R T L R A L R P L R A L S R F E G M R V V V N A L L G A I P S I M N V L L V C L I F W L I F S I M G V N L F A G K F Y H C I N T T T G D R F D I E D V N N H T D C L K L I E R N E T A R W K N V K V N F D N V G F G Y L S L L Q V A T F K G W M D I M Y A A V D S R N V E L Q P K Y E E S L Y M Y L Y F V I F I I F G S F F T L N L F I G V I I D N F N Q Q K K K F G G Q D I F M T E E Q K K Y Y N A M K K L G S K K P Q K P I P R P G N K F Q G M V F D F V T R Q V F D I S I M I L I C L N M V T M M V E T D D Q S E Y V T T I L S R I N L V F I V L F T G E C V L K L I S L R H Y Y F T I G W N I F D F V V V I L S I V G M F L A E L I E K Y F V S P T L F R V I R L A R I G R I L R L I K G A K G I R T L L F A L M M S L P A L F N I G L L L F L V M F I Y A I F G M S N F A Y V K R E V G I D D M F N F E T F G N S M I C L F Q I T T S A G W D G L L A P I L N S K P P D C D P N K V N P G S S V K G D C G N P S V G I F F F V S Y I I I S F L V V V N M Y I A V I L E N F S V A T E E S A E P L S E D D F E M F Y E V W E K F D P D A T Q F M E F E K L S Q F A A A L E P P L N L P Q P N K L Q L I A M D L P M V S G D R I H C L D I L F A F T K R V L G E S G E M D A L R I Q M E E R F M A S N P S K V S Y Q P I T T T L K R K Q E E V S A V I I Q R A Y R R H L L K R T V K Q A S F T Y N K N K I K G G A N L L I K E D M I I D R I N E N S I T E K T D L T M S T A A C P P S Y D R V T K P I V E K H E Q E G K D E K A K G K
PTM type	X-Acetylation X-Methylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-SUMOylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1506
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SCN1A Lysine 1506 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1936
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SCN1A Lysine 1936 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1946
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SCN1A Lysine 1946 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SCN1A Lysine 1948 has the potential to affect its expression or activity.
Methylation
Arginine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Arginine	Modified Location	563
Related Enzyme	Protein arginine N-methyltransferase 1 (PRMT1)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SCN1A Arginine 563 have been reported to have the potential to influence its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Arginine	Modified Location	570
Related Enzyme	Protein arginine N-methyltransferase 1 (PRMT1)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SCN1A Arginine 570 have been reported to have the potential to influence its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Arginine	Modified Location	574
Related Enzyme	Protein arginine N-methyltransferase 1 (PRMT1)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SCN1A Arginine 574 have been reported to have the potential to influence its expression or activity.
N-glycosylation
Asparagine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	211
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 211 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	284
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 284 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	295
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 295 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	301
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 301 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	306
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 306 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	338
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 338 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1378
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 1378 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1392
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 1392 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SCN1A			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1403
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SCN1A Asparagine 1403 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	179
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SCN1A Cystine 179 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1982
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SCN1A Cystine 1982 has the potential to affect its expression or activity.
Phosphorylation
Arginine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[8]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	693
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Arginine 693 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[8]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	710
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Arginine 710 has the potential to affect its expression or activity.
Serine	33 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Slowing the inactivation of sodium channels and reducing peak sodium currents			[9]
Role of PTM	Protein Activity Modulation
Modified Residue	Serine	Modified Location	1516
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1516 have been reported to slow the inactivation of sodium channels and reducing peak sodium currents.
PTM Phenomenon2	Have the potential to influence SCN1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	169
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 169 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	316
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 316 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	321
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 321 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SCN1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	374
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 374 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SCN1A			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	474
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 474 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SCN1A			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	480
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 480 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SCN1A			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 482 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SCN1A			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	483
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 483 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SCN1A			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	487
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 487 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SCN1A			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	490
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 490 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SCN1A			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	491
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 491 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SCN1A			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	510
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 510 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SCN1A			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	523
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 523 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 525 has the potential to affect its expression or activity.
PTM Phenomenon16	.			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 525 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 528 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SCN1A			[14], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	550
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 550 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SCN1A			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 551 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	555
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 555 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	558
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 558 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	562
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 562 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence SCN1A			[8], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	565
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 565 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence SCN1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	576
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 576 has the potential to affect its expression or activity.
PTM Phenomenon25	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	607
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 607 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence SCN1A			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	718
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 718 has the potential to affect its expression or activity.
PTM Phenomenon27	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	730
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 730 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence SCN1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	856
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 856 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence SCN1A			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1037
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1037 has the potential to affect its expression or activity.
PTM Phenomenon30	.			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1063
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1063 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence SCN1A			[22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1566
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1566 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence SCN1A			[23]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1631 has the potential to affect its expression or activity.
PTM Phenomenon33	Have the potential to influence SCN1A			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1918
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Serine 1918 has the potential to affect its expression or activity.
Threonine	18 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 297 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	303
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 303 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	308
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 308 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	544
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 544 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SCN1A			[8], [20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	721
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 721 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SCN1A			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	723
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 723 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1066
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1066 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SCN1A			[22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1562
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1562 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SCN1A			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1633
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1633 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1908
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1908 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1909
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1909 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1909
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1909 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1909
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1909 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1934 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1934 has the potential to affect its expression or activity.
PTM Phenomenon16	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1934 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1934 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Threonine 1934 has the potential to affect its expression or activity.
Tyrosine	16 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Increasing SCN1A expression at the cell surface			[5]
Role of PTM	Surface Expression Modulation
Affected Drug/Substrate	Sodium	Results for Drug	Increasing the transport of sodium
Modified Residue	Tyrosine	Modified Location	1495
Related Enzyme	Tyrosine-protein kinase Fyn (FYN)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1495 have been reported to increase its expression at the cell surface.
PTM Phenomenon2	Impairing the function of SCN1A			[5]
Role of PTM	Trafficking to Plasma Membrane
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Tyrosine	Modified Location	1498
Related Enzyme	Tyrosine-protein kinase Fyn (FYN)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1498 have been reported to impaire its transport function.
PTM Phenomenon3	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Tyrosine	Modified Location	66
Related Enzyme	Tyrosine-protein kinase Fyn (FYN)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 66 have been reported to have the potential to influence its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	300
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 300 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SCN1A			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	317
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 317 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	545
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 545 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SCN1A			[18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	549
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 549 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Tyrosine	Modified Location	1497
Related Enzyme	Tyrosine-protein kinase Fyn (FYN)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1497 have been reported to have the potential to influence its expression or activity.
PTM Phenomenon9	Have the potential to influence SCN1A			[26], [27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1507
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1507 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SCN1A			[26], [28]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1508
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1508 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1684
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1684 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1684
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1684 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1684
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1684 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1694
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1694 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Affecting the inward transport of sodium
Modified Residue	Tyrosine	Modified Location	1893
Related Enzyme	Tyrosine-protein kinase Fyn (FYN)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1893 have been reported to have the potential to influence its expression or activity.
PTM Phenomenon16	.			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1926
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SCN1A Tyrosine 1926 has the potential to affect its expression or activity.
SUMOylation
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[29]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	167
Experimental Material(s)	E. coli BL21
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SCN1A Lysine 167 have been reported to facilitated the formation of NAC1 nuclear bodies.
PTM Phenomenon2	.			[29]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	318
Experimental Material(s)	E. coli BL21
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SCN1A Lysine 318 have been reported to facilitated the formation of NAC1 nuclear bodies.
PTM Phenomenon3	.			[29]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	368
Experimental Material(s)	E. coli BL21
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SCN1A Lysine 368 have been reported to facilitated the formation of NAC1 nuclear bodies.
PTM Phenomenon4	.			[29]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	498
Experimental Material(s)	E. coli BL21
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SCN1A Lysine 498 have been reported to facilitated the formation of NAC1 nuclear bodies.
Ubiquitination
Lysine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SCN1A			[5]
Role of PTM	Potential impacts
Affected Drug/Substrate	Sodium	Results for Drug	Decreasing the transport of sodium
Modified Residue	Lysine
Related Enzyme	E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine have been reported to has the potential to affect its expression or activity.
PTM Phenomenon2	.			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine 88 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SCN1A			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	225
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine 225 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SCN1A			[31]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	453
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine 453 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine 1512 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SCN1A Lysine 1512 has the potential to affect its expression or activity.

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