Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0503 Transporter Info
Gene Name	SLCO4C1
Transporter Name	Organic anion transporting polypeptide 4C1
Gene ID	353189
UniProt ID	Q6ZQN7

Post-Translational Modification of This DT
Overview ofSLCO4C1 Modification Sites with Functional and Structural Information
Sequence	M K S A K G I E N L A F V P S S P D I L R R L S A S P S Q I E V S A L S S D P Q R E N S Q P Q E L Q K P Q E P Q K S P E P S L P S A P P N V S E E K L R S L S L S E F E E G S Y G W R N F H P Q C L Q R C N T P G G F L L H Y C L L A V T Q G I V V N G L V N I S I S T V E K R Y E M K S S L T G L I S S S Y D I S F C L L S L F V S F F G E R G H K P R W L A F A A F M I G L G A L V F S L P Q F F S G E Y K L G S L F E D T C V T T R N S T S C T S S T S S L S N Y L Y V F I L G Q L L L G A G G T P L Y T L G T A F L D D S V P T H K S S L Y I G T G Y A M S I L G P A I G Y V L G G Q L L T I Y I D V A M G E S T D V T E D D P R W L G A W W I G F L L S W I F A W S L I I P F S C F P K H L P G T A E I Q A G K T S Q A H Q S N S N A D V K F G K S I K D F P A A L K N L M K N A V F M C L V L S T S S E A L I T T G F A T F L P K F I E N Q F G L T S S F A A T L G G A V L I P G A A L G Q I L G G F L V S K F R M T C K N T M K F A L F T S G V A L T L S F V F M Y A K C E N E P F A G V S E S Y N G T G E L G N L I A P C N A N C N C S R S Y Y Y P V C G D G V Q Y F S P C F A G C S N P V A H R K P K V Y Y N C S C I E R K T E I T S T A E T F G F E A K A G K C E T H C A K L P I F L C I F F I V I I F T F M A G T P I T V S I L R C V N H R Q R S L A L G I Q F M V L R L L G T I P G P I I F G F T I D S T C I L W D I N D C G I K G A C W I Y D N I K M A H M L V A I S V T C K V I T M F F N G F A I F L Y K P P P S A T D V S F H K E N A V V T N V L A E Q D L N K I V K E G
PTM type	X-O-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

O-glycosylation
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO4C1			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	557
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at SLCO4C1 Threonine 557 has the potential to affect its expression or activity.
Phosphorylation
Serine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO4C1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	15
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 15 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO4C1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	16
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 16 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO4C1			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	24
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 24 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO4C1			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 26 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLCO4C1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 28 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLCO4C1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 33 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLCO4C1			[2], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	77
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 77 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLCO4C1			[2], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	79
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 79 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLCO4C1			[2], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 81 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLCO4C1			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	461
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Serine 461 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO4C1			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	460
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Threonine 460 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO4C1			[8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	473
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO4C1 Tyrosine 473 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	363
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO4C1 Lysine 363 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	363
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO4C1 Lysine 363 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	363
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO4C1 Lysine 363 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SO4C1_HUMAN)
2	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
3	Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL. Blood Adv. 2018 Oct 9;2(19):2554-2567.
4	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
5	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
6	Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 Dec 17;80(6):1104-1122.e9.
7	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
8	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501.
9	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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