Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0490 Transporter Info
Gene Name	SLC9A6
Transporter Name	Sodium/hydrogen exchanger 6
Gene ID	10479
UniProt ID	Q92581

Post-Translational Modification of This DT
Overview ofSLC9A6 Modification Sites with Functional and Structural Information
Sequence	M A R R G W R R A P L R R G V G S S P R A R R L M R P L W L L L A V G V F D W A G A S D G G G G E A R A M D E E I V S E K Q A E E S H R Q D S A N L L I F I L L L T L T I L T I W L F K H R R A R F L H E T G L A M I Y G L L V G L V L R Y G I H V P S D V N N V T L S C E V Q S S P T T L L V T F D P E V F F N I L L P P I I F Y A G Y S L K R R H F F R N L G S I L A Y A F L G T A I S C F V I G S I M Y G C V T L M K V T G Q L A G D F Y F T D C L L F G A I V S A T D P V T V L A I F H E L Q V D V E L Y A L L F G E S V L N D A V A I V L S S S I V A Y Q P A G D N S H T F D V T A M F K S I G I F L G I F S G S F A M G A A T G V V T A L V T K F T K L R E F Q L L E T G L F F L M S W S T F L L A E A W G F T G V V A V L F C G I T Q A H Y T Y N N L S T E S Q H R T K Q L F E L L N F L A E N F I F S Y M G L T L F T F Q N H V F N P T F V V G A F V A I F L G R A A N I Y P L S L L L N L G R R S K I G S N F Q H M M M F A G L R G A M A F A L A I R D T A T Y A R Q M M F S T T L L I V F F T V W V F G G G T T A M L S C L H I R V G V D S D Q E H L G V P E N E R R T T K A E S A W L F R M W Y N F D H N Y L K P L L T H S G P P L T T T L P A C C G P I A R C L T S P Q A Y E N Q E Q L K D D D S D L I L N D G D I S L T Y G D S T V N T E P A T S S A P R R F M G N S S E D A L D R E L A F G D H E L V I R G T R L V L P M D D S E P P L N L L D N T R H G P A
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	128
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC9A6 Asparagine 128 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	571
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC9A6 Cystine 571 has the potential to affect its expression or activity.
Phosphorylation
Serine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 166 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A6			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	446
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 446 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	480
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 480 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	502
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 502 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A6			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	574
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 574 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A6			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	589
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 589 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC9A6			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	599
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 599 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC9A6			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	605
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 605 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC9A6			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	614
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 614 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC9A6			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	615
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 615 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC9A6			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	624
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 624 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC9A6			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	625
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 625 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC9A6			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	654
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Serine 654 has the potential to affect its expression or activity.
Threonine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 481 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 482 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 489 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	497
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 497 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A6			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	498
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 498 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A6			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	573
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 573 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC9A6			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	601
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 601 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC9A6			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	606
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 606 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC9A6			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	609
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 609 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC9A6			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	613
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Threonine 613 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	602
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A6 Tyrosine 602 has the potential to affect its expression or activity.
Ubiquitination
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A6			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	443
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A6 Lysine 443 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A6 Lysine 528 has the potential to affect its expression or activity.

References
1	Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61.
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
5	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
6	Protein kinase C-alpha interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13;290(11):7054-66.
7	Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep. 2014 Sep 11;8(5):1583-94.
8	Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab. Neoplasia. 2018 Jul;20(7):668-677.
9	MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene. 2018 Aug;37(33):4518-4533.
10	Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res. 2017 Mar 3;16(3):1121-1132.
11	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
12	Glycoprotein capture and quantitative phosphoproteomics indicate coordinated regulation of cell migration upon lysophosphatidic acid stimulation. Mol Cell Proteomics. 2010 Nov;9(11):2337-53.
13	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
14	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
15	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
16	Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Proteomics. 2007 Mar;7(6):868-74.
17	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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