Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0394 Transporter Info
Gene Name	SLC52A2
Transporter Name	Riboflavin transporter 3
Gene ID	79581
UniProt ID	Q9HAB3

Post-Translational Modification of This DT
Overview ofSLC52A2 Modification Sites with Functional and Structural Information
Sequence	M A A P T P A R P V L T H L L V A L F G M G S W A A V N G I W V E L P V V V K E L P E G W S L P S Y V S V L V A L G N L G L L V V T L W R R L A P G K D E Q V P I R V V Q V L G M V G T A L L A S L W H H V A P V A G Q L H S V A F L A L A F V L A L A C C A S N V T F L P F L S H L P P R F L R S F F L G Q G L S A L L P C V L A L V Q G V G R L E C P P A P I N G T P G P P L D F L E R F P A S T F F W A L T A L L V A S A A A F Q G L L L L L P P P P S V P T G E L G S G L Q V G A P G A E E E V E E S S P L Q E P P S Q A A G T T P G P D P K A Y Q L L S A R S A C L L G L L A A T N A L T N G V L P A V Q S F S C L P Y G R L A Y H L A V V L G S A A N P L A C F L A M G V L C R S L A G L G G L S L L G V F C G G Y L M A L A V L S P C P P L V G T S A G V V L V V L S W V L C L G V F S Y V K V A A S S L L H G G G R P A L L A A G V A I Q V G S L L G A V A M F P P T S I Y H V F H S R K D C A D P C D S
PTM type	X-Phosphorylation X-Phosphorylation X-SUMOylation X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC52A2			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	273
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC52A2 Serine 273 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC52A2 Tyrosine 305 has the potential to affect its expression or activity.
SUMOylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	267
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC52A2 Lysine 267 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	75
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC52A2 Lysine 75 has the potential to affect its expression or activity.

References
1	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
2	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
3	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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