Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0291 Transporter Info
Gene Name	SLC35A5
Transporter Name	Probable UDP-sugar transporter protein SLC35A5
Gene ID	55032
UniProt ID	Q9BS91

Post-Translational Modification of This DT
Overview ofSLC35A5 Modification Sites with Functional and Structural Information
Sequence	M E K Q C C S H P V I C S L S T M Y T F L L G A I F I A L S S S R I L L V K Y S A N E E N K Y D Y L P T T V N V C S E L V K L V F C V L V S F C V I K K D H Q S R N L K Y A S W K E F S D F M K W S I P A F L Y F L D N L I V F Y V L S Y L Q P A M A V I F S N F S I I T T A L L F R I V L K R R L N W I Q W A S L L T L F L S I V A L T A G T K T L Q H N L A G R G F H H D A F F S P S N S C L L F R S E C P R K D N C T A K E W T F P E A K W N T T A R V F S H I R L G M G H V L I I V Q C F I S S M A N I Y N E K I L K E G N Q L T E S I F I Q N S K L Y F F G I L F N G L T L G L Q R S N R D Q I K N C G F F Y G H S A F S V A L I F V T A F Q G L S V A F I L K F L D N M F H V L M A Q V T T V I I T T V S V L V F D F R P S L E F F L E A P S V L L S I F I Y N A S K P Q V P E Y A P R Q E R I R D L S G N L W E R S S G D G E E L E R L T K P K S D E S D E D T F
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC35A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	204
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC35A5 Asparagine 204 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC35A5			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	87
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 87 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	288
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 288 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC35A5			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	394
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 394 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC35A5			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 401 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC35A5			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	402
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 402 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC35A5			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	416
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 416 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC35A5			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Serine 419 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC35A5			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Threonine 170 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC35A5			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	412
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Threonine 412 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC35A5			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	423
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC35A5 Threonine 423 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S35A5_HUMAN)
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
4	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
5	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
6	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
7	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
8	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
9	Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 Dec 17;80(6):1104-1122.e9.
10	Protein kinase PKN1 represses Wnt/beta-catenin signaling in human melanoma cells. J Biol Chem. 2013 Nov 29;288(48):34658-70.
11	Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res. 2017 Mar 3;16(3):1121-1132.
12	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
13	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.

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Detail Information of Post-Translational Modifications

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