Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0249 Transporter Info
Gene Name	SLC29A3
Transporter Name	Equilibrative nucleoside transporter 3
Gene ID	55315
UniProt ID	Q9BZD2

Post-Translational Modification of This DT
Overview ofSLC29A3 Modification Sites with Functional and Structural Information
Sequence	M A V V S E D D F Q H S S N S T Y R T T S S S L R A D Q E A L L E K L L D R P P P G L Q R P E D R F C G T Y I I F F S L G I G S L L P W N F F I T A K E Y W M F K L R N S S S P A T G E D P E G S D I L N Y F E S Y L A V A S T V P S M L C L V A N F L L V N R V A V H I R V L A S L T V I L A I F M V I T A L V K V D T S S W T R G F F A V T I V C M V I L S G A S T V F S S S I Y G M T G S F P M R N S Q A L I S G G A M G G T V S A V A S L V D L A A S S D V R N S A L A F F L T A T V F L V L C M G L Y L L L S R L E Y A R Y Y M R P V L A A H V F S G E E E L P Q D S L S A P S V A S R F I D S H T P P L R P I L K K T A S L G F C V T Y V F F I T S L I Y P A I C T N I E S L N K G S G S L W T T K F F I P L T T F L L Y N F A D L C G R Q L T A W I Q V P G P N S K A L P G F V L L R T C L I P L F V L C N Y Q P R V H L K T V V F Q S D V Y P A L L S S L L G L S N G Y L S T L A L L Y G P K I V P R E L A E A T G V V M S F Y V C L G L T L G S A C S T L L V H L I
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC29A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	84
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC29A3 Asparagine 84 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC29A3			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	5
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 5 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC29A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 12 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC29A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	13
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 13 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC29A3			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	15
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 15 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC29A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 21 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC29A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 22 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC29A3			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	23
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Serine 23 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC29A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	16
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Threonine 16 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC29A3			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Threonine 19 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC29A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	20
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Threonine 20 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC29A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC29A3 Tyrosine 17 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S29A3_HUMAN)
2	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
3	Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Mol Cell Proteomics. 2016 Oct;15(10):3203-3219.
4	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
5	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
6	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
7	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.

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Detail Information of Post-Translational Modifications

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