Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0245 Transporter Info
Gene Name	SLC28A2
Transporter Name	Concentrative nucleoside transporter 2
Gene ID	9153
UniProt ID	O43868

Post-Translational Modification of This DT
Overview ofSLC28A2 Modification Sites with Functional and Structural Information
Sequence	M E K A S G R Q S I A L S T V E T G T V N P G L E L M E K E V E P E G S K R T D A Q G H S L G D G L G P S T Y Q R R S R W P F S K A R S F C K T H A S L F K K I L L G L L C L A Y A A Y L L A A C I L N F Q R A L A L F V I T C L V I F V L V H S F L K K L L G K K L T R C L K P F E N S R L R L W T K W V F A G V S L V G L I L W L A L D T A Q R P E Q L I P F A G I C M F I L I L F A C S K H H S A V S W R T V F S G L G L Q F V F G I L V I R T D L G Y T V F Q W L G E Q V Q I F L N Y T V A G S S F V F G D T L V K D V F A F Q A L P I I I F F G C V V S I L Y Y L G L V Q W V V Q K V A W F L Q I T M G T T A T E T L A V A G N I F V G M T E A P L L I R P Y L G D M T L S E I H A V M T G G F A T I S G T V L G A F I A F G V D A S S L I S A S V M A A P C A L A S S K L A Y P E V E E S K F K S E E G V K L P R G K E R N V L E A A S N G A V D A I G L A T N V A A N L I A F L A V L A F I N A A L S W L G E L V D I Q G L T F Q V I C S Y L L R P M V F M M G V E W T D C P M V A E M V G I K F F I N E F V A Y Q Q L S Q Y K N K R L S G M E E W I E G E K Q W I S V R A E I I T T F S L C G F A N L S S I G I T L G G L T S I V P H R K S D L S K V V V R A L F T G A C V S L I S A C M A G I L Y V P R G A E A D C V S F P N T S F T N R T Y E T Y M C C R G L F Q S T S L N G T N P P S F S G P W E D K E F S A M A L T N C C G F Y N N T V C A
PTM type	X-Methylation X-Phosphorylation X-Phosphorylation X: Amino Acid

Methylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	78
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SLC28A2 Lysine 78 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	79
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SLC28A2 Lysine 79 has the potential to affect its expression or activity.
Phosphorylation
Serine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC28A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Serine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	45
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Serine 45 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC28A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	75
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Serine 75 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC28A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Serine 121 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC28A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Serine 500 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC28A2			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A2 Threonine 19 has the potential to affect its expression or activity.

References
1	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networks. Sci Rep. 2015 Dec 11;5:18189.
4	BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. Nucleic Acids Res. 2018;46(D1):D1128-D1136.

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Detail Information of Post-Translational Modifications

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