Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0244 Transporter Info
Gene Name	SLC28A1
Transporter Name	Concentrative nucleoside transporter 1
Gene ID	9154
UniProt ID	O00337

Post-Translational Modification of This DT
Overview ofSLC28A1 Modification Sites with Functional and Structural Information
Sequence	M E N D P S R R R E S I S L T P V A K G L E N M G A D F L E S L E E G Q L P R S D L S P A E I R S S W S E A A P K P F S R W R N L Q P A L R A R S F C R E H M Q L F R W I G T G L L C T G L S A F L L V A C L L D F Q R A L A L F V L T C V V L T F L G H R L L K R L L G P K L R R F L K P Q G H P R L L L W F K R G L A L A A F L G L V L W L S L D T S Q R P E Q L V S F A G I C V F V A L L F A C S K H H C A V S W R A V S W G L G L Q F V L G L L V I R T E P G F I A F E W L G E Q I R I F L S Y T K A G S S F V F G E A L V K D V F A F Q V L P I I V F F S C V I S V L Y H V G L M Q W V I L K I A W L M Q V T M G T T A T E T L S V A G N I F V S Q T E A P L L I R P Y L A D M T L S E V H V V M T G G Y A T I A G S L L G A Y I S F G I D A T S L I A A S V M A A P C A L A L S K L V Y P E V E E S K F R R E E G V K L T Y G D A Q N L I E A A S T G A A I S V K V V A N I A A N L I A F L A V L D F I N A A L S W L G D M V D I Q G L S F Q L I C S Y I L R P V A F L M G V A W E D C P V V A E L L G I K L F L N E F V A Y Q D L S K Y K Q R R L A G A E E W V G D R K Q W I S V R A E V L T T F A L C G F A N F S S I G I M L G G L T S M V P Q R K S D F S Q I V L R A L F T G A C V S L V N A C M A G I L Y M P R G A E V D C M S L L N T T L S S S S F E I Y Q C C R E A F Q S V N P E F S P E A L D N C C R F Y N H T I C A Q
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC28A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	605
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC28A1 Asparagine 605 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC28A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	643
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC28A1 Asparagine 643 has the potential to affect its expression or activity.
Phosphorylation
Serine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC28A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	11
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 11 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC28A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	13
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 13 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC28A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	31
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 31 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC28A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 40 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC28A1			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	43
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 43 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC28A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 49 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC28A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 50 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC28A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	52
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 52 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC28A1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	73
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Serine 73 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC28A1			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	15
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC28A1 Threonine 15 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S28A1_HUMAN)
2	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
3	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
4	Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Sci Signal. 2015 Apr 28;8(374):ra40.
5	TiO2 with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):710-721.
6	Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network. Proteomics. 2016 Jul;16(14):1992-7.

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Detail Information of Post-Translational Modifications

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