Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0164 Transporter Info
Gene Name	SLC24A3
Transporter Name	Sodium/potassium/calcium exchanger 3
Gene ID	57419
UniProt ID	Q9HC58

Post-Translational Modification of This DT
Overview ofSLC24A3 Modification Sites with Functional and Structural Information
Sequence	M R P S G D E D R A R R R R R R R R R R D L L L S Q L C F L A S V A L L L W S L S S L R E Q K E L D L M D L V G E D R K W M M A R K L M Q V N D T L T S E D A G L R N S K N C T E P A L H E F P N D I F T N E D R R Q G A V V L H V L C A I Y M F Y A L A I V C D D F F V P S L E K I C E R L H L S E D V A G A T F M A A G S S A P E L F T S V I G V F I T K G D V G V G T I V G S A V F N I L C I I G V C G L F A G Q V V A L S S W C L L R D S I Y Y T L S V I A L I V F I Y D E K V S W W E S L V L V L M Y L I Y I V I M K Y N A C I H Q C F E R R T K G A G N M V N G L A N N A E I D D S S N C D A T V V L L K K A N F H R K A S V I M V D E L L S A Y P H Q L S F S E A G L R I M I T S H F P P K T R L S M A S R M L I N E R Q R L I N S R A Y T N G E S E V A I K I P I K H T V E N G T G P S S A P D R G V N G T R R D D V V A E A G N E T E N E N E D N E N D E E E E E D E D D D E G P Y T P F D T P S G K L E T V K W A F T W P L S F V L Y F T V P N C N K P R W E K W F M V T F A S S T L W I A A F S Y M M V W M V T I I G Y T L G I P D V I M G I T F L A A G T S V P D C M A S L I V A R Q G M G D M A V S N S I G S N V F D I L I G L G L P W A L Q T L A V D Y G S Y I R L N S R G L I Y S V G L L L A S V F V T V F G V H L N K W Q L D K K L G C G C L L L Y G V F L C F S I M T E F N V F T F V N L P M C G D H
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	71
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC24A3 Asparagine 71 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	86
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC24A3 Asparagine 86 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A3			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	39
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 39 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	41
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 41 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC24A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	42
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 42 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC24A3			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	288
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 288 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC24A3			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	308
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 308 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC24A3			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	361
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Serine 361 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A3			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	294
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Threonine 294 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	365
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Threonine 365 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC24A3			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	398
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Threonine 398 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A3			[8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	364
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A3 Tyrosine 364 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: NCKX3_HUMAN)
2	Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability. Mol Biol Cell. 2018 May 1;29(9):1031-1047.
3	Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL. Blood Adv. 2018 Oct 9;2(19):2554-2567.
4	Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen. Mol Cell Proteomics. 2016 Mar;15(3):1032-47.
5	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
6	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
7	Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10.
8	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
9	Citric acid-assisted two-step enrichment with TiO2 enhances the separation of multi- and monophosphorylated peptides and increases phosphoprotein profiling. J Proteome Res. 2013 Jun 7;12(6):2467-76.

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Detail Information of Post-Translational Modifications

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