Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0152 Transporter Info
Gene Name	SLC22A9
Transporter Name	Organic anion transporter 7
Gene ID	114571
UniProt ID	Q8IVM8

Post-Translational Modification of This DT
Overview ofSLC22A9 Modification Sites with Functional and Structural Information
Sequence	M A F Q D L L G H A G D L W R F Q I L Q T V F L S I F A V A T Y L H F M L E N F T A F I P G H R C W V H I L D N D T V S D N D T G A L S Q D A L L R I S I P L D S N M R P E K C R R F V H P Q W Q L L H L N G T F P N T S D A D M E P C V D G W V Y D R I S F S S T I V T E W D L V C D S Q S L T S V A K F V F M A G M M V G G I L G G H L S D R F G R R F V L R W C Y L Q V A I V G T C A A L A P T F L I Y C S L R F L S G I A A M S L I T N T I M L I A E W A T H R F Q A M G I T L G M C P S G I A F M T L A G L A F A I R D W H I L Q L V V S V P Y F V I F L T S S W L L E S A R W L I I N N K P E E G L K E L R K A A H R S G M K N A R D T L T L E I L K S T M K K E L E A A Q K K K P S L C E M L H M P N I C K R I S L L S F T R F A N F M A Y F G L N L H V Q H L G N N V F L L Q T L F G A V I L L A N C V A P W A L K Y M N R R A S Q M L L M F L L A I C L L A I I F V P Q E M Q T L R E V L A T L G L G A S A L A N T L A F A H G N E V I P T I I R A R A M G I N A T F A N I A G A L A P L M M I L S V Y S P P L P W I I Y G V F P F I S G F A F L L L P E T R N K P L F D T I Q D E K N E R K D P R E P K Q E D P R V E V T Q F
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	39
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A9 Asparagine 39 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	56
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A9 Asparagine 56 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	102
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A9 Asparagine 102 has the potential to affect its expression or activity.
Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A9			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A9 Serine 81 has the potential to affect its expression or activity.
Ubiquitination
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	321
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A9 Lysine 321 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	321
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A9 Lysine 321 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S22A9_HUMAN)
2	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
3	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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