Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0098 Transporter Info
Gene Name	SLC15A3
Transporter Name	Peptide/histidine transporter 2
Gene ID	51296
UniProt ID	Q8IY34

Post-Translational Modification of This DT
Overview ofSLC15A3 Modification Sites with Functional and Structural Information
Sequence	M P A P R A R E Q P R V P G E R Q P L L P R G A R G P R R W R R A A G A A V L L V E M L E R A A F F G V T A N L V L Y L N S T N F N W T G E Q A T R A A L V F L G A S Y L L A P V G G W L A D V Y L G R Y R A V A L S L L L Y L A A S G L L P A T A F P D G R S S F C G E M P A S P L G P A C P S A G C P R S S P S P Y C A P V L Y A G L L L L G L A A S S V R S N L T S F G A D Q V M D L G R D A T R R F F N W F Y W S I N L G A V L S L L V V A F I Q Q N I S F L L G Y S I P V G C V G L A F F I F L F A T P V F I T K P P M G S Q V S S M L K L A L Q N C C P Q L W Q R H S A R D R Q C A R V L A D E R S P Q P G A S P Q E D I A N F Q V L V K I L P V M V T L V P Y W M V Y F Q M Q S T Y V L Q G L H L H I P N I F P A N P A N I S V A L R A Q G S S Y T I P E A W L L L A N V V V V L I L V P L K D R L I D P L L L R C K L L P S A L Q K M A L G M F F G F T S V I V A G V L E M E R L H Y I H H N E T V S Q Q I G E V L Y N A A P L S I W W Q I P Q Y L L I G I S E I F A S I P G L E F A Y S E A P R S M Q G A I M G I F F C L S G V G S L L G S S L V A L L S L P G G W L H C P K D F G N I N N C R M D L Y F F L L A G I Q A V T A L L F V W I A G R Y E R A S Q G P A S H S R F S R D R G
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	61
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 61 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 66 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	178
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 178 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	223
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 223 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	356
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 356 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC15A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	439
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC15A3 Asparagine 439 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC15A3			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC15A3 Cystine 536 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC15A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	572
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC15A3 Serine 572 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC15A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	574
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC15A3 Serine 574 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC15A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC15A3 Serine 577 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S15A3_HUMAN)
2	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
3	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.

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Detail Information of Post-Translational Modifications

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