Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0084 Transporter Info
Gene Name	SLC12A3
Transporter Name	Thiazide-sensitive sodium-chloride cotransporter
Gene ID	6559
UniProt ID	P55017

Post-Translational Modification of This DT
Overview ofSLC12A3 Modification Sites with Functional and Structural Information
Sequence	M A E L P T T E T P G D A T L C S G R F T I S T L L S S D E P S P P A A Y D S S H P S H L T H S S T F C M R T F G Y N T I D V V P T Y E H Y A N S T Q P G E P R K V R P T L A D L H S F L K Q E G R H L H A L A F D S R P S H E M T D G L V E G E A G T S S E K N P E E P V R F G W V K G V M I R C M L N I W G V I L Y L R L P W I T A Q A G I V L T W I I I L L S V T V T S I T G L S I S A I S T N G K V K S G G T Y F L I S R S L G P E L G G S I G L I F A F A N A V G V A M H T V G F A E T V R D L L Q E Y G A P I V D P I N D I R I I A V V S V T V L L A I S L A G M E W E S K A Q V L F F L V I M V S F A N Y L V G T L I P P S E D K A S K G F F S Y R A D I F V Q N L V P D W R G P D G T F F G M F S I F F P S A T G I L A G A N I S G D L K D P A I A I P K G T L M A I F W T T I S Y L A I S A T I G S C V V R D A S G V L N D T V T P G W G A C E G L A C S Y G W N F T E C T Q Q H S C H Y G L I N Y Y Q T M S M V S G F A P L I T A G I F G A T L S S A L A C L V S A A K V F Q C L C E D Q L Y P L I G F F G K G Y G K N K E P V R G Y L L A Y A I A V A F I I I A E L N T I A P I I S N F F L C S Y A L I N F S C F H A S I T N S P G W R P S F Q Y Y N K W A A L F G A I I S V V I M F L L T W W A A L I A I G V V L F L L L Y V I Y K K P E V N W G S S V Q A G S Y N L A L S Y S V G L N E V E D H I K N Y R P Q C L V L T G P P N F R P A L V D F V G T F T R N L S L M I C G H V L I G P H K Q R M P E L Q L I A N G H T K W L N K R K I K A F Y S D V I A E D L R R G V Q I L M Q A A G L G R M K P N I L V V G F K K N W Q S A H P A T V E D Y I G I L H D A F D F N Y G V C V M R M R E G L N V S K M M Q A H I N P V F D P A E D G K E A S A R V D P K A L V K E E Q A T T I F Q S E Q G K K T I D I Y W L F D D G G L T L L I P Y L L G R K R R W S K C K I R V F V G G Q I N R M D Q E R K A I I S L L S K F R L G F H E V H I L P D I N Q N P R A E H T K R F E D M I A P F R L N D G F K D E A T V N E M R R D C P W K I S D E E I T K N R V K S L R Q V R L N E I V L D Y S R D A A L I V I T L P I G R K G K C P S S L Y M A W L E T L S Q D L R P P V I L I R G N Q E N V L T F Y C Q
PTM type	X-Acetylation X-N-glycosylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A3			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	140
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A3 Lysine 140 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A3			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	734
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A3 Lysine 734 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A3			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	743
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A3 Lysine 743 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A3			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	885
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC12A3 Lysine 885 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A3			[5]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	406
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A3 Asparagine 406 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A3			[5]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	426
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC12A3 Asparagine 426 has the potential to affect its expression or activity.
Phosphorylation
Serine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A3			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 17 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	43
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 43 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A3			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	73
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 73 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A3			[6], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	91
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 91 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	126
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 126 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	126
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 126 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC12A3			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	178
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 178 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	309
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 309 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC12A3			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	804
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 804 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC12A3			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	881
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 881 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	884
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Serine 884 has the potential to affect its expression or activity.
Threonine	16 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A3			[6], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A3			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 7 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A3			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 9 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A3			[6], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	14
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 14 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A3			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	46
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 46 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 50 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 50 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC12A3			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	55
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 55 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC12A3			[6], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	60
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 60 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC12A3			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 66 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC12A3			[6], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	74
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 74 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	85
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 85 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	124
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 124 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	697
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 697 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC12A3			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	753
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 753 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC12A3			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	820
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Threonine 820 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC12A3			[17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	58
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Tyrosine 58 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC12A3			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	67
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Tyrosine 67 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC12A3			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	70
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Tyrosine 70 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC12A3			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	757
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Tyrosine 757 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC12A3			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	769
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC12A3 Tyrosine 769 has the potential to affect its expression or activity.
Ubiquitination
Lysine	33 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 81 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 81 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 81 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	94
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 94 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	94
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 94 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 128 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 128 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 128 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	199
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 199 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	784
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 784 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	784
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 784 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	784
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 784 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	801
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 801 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	801
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 801 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	801
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 801 has the potential to affect its expression or activity.
PTM Phenomenon16	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	810
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 810 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	810
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 810 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	810
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 810 has the potential to affect its expression or activity.
PTM Phenomenon19	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	814
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 814 has the potential to affect its expression or activity.
PTM Phenomenon20	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	814
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 814 has the potential to affect its expression or activity.
PTM Phenomenon21	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	828
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 828 has the potential to affect its expression or activity.
PTM Phenomenon22	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	828
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 828 has the potential to affect its expression or activity.
PTM Phenomenon23	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	877
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 877 has the potential to affect its expression or activity.
PTM Phenomenon24	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	925
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 925 has the potential to affect its expression or activity.
PTM Phenomenon25	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	925
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 925 has the potential to affect its expression or activity.
PTM Phenomenon26	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon27	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon28	.			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon29	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon30	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon31	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 948 has the potential to affect its expression or activity.
PTM Phenomenon32	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 948 has the potential to affect its expression or activity.
PTM Phenomenon33	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC12A3 Lysine 948 has the potential to affect its expression or activity.

References
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11	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
12	Fast Global Phosphoproteome Profiling of Jurkat T Cells by HIFU-TiO2-SCX-LC-MS/MS. Anal Chem. 2017 Sep 5;89(17):8853-8862.
13	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
14	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
15	MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J. 2011 May 4;30(9):1730-41.
16	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
17	Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. Methods. 2012 Feb;56(2):268-74.
18	Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography. J Proteomics. 2013 Oct 8;91:331-7.

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Detail Information of Post-Translational Modifications

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