Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0060 Transporter Info
Gene Name	ABCC7
Transporter Name	Cystic fibrosis transmembrane conductance regulator
Gene ID	1080
UniProt ID	P13569

Post-Translational Modification of This DT
Overview ofABCC7 Modification Sites with Functional and Structural Information
Sequence	M Q R S P L E K A S V V S K L F F S W T R P I L R K G Y R Q R L E L S D I Y Q I P S V D S A D N L S E K L E R E W D R E L A S K K N P K L I N A L R R C F F W R F M F Y G I F L Y L G E V T K A V Q P L L L G R I I A S Y D P D N K E E R S I A I Y L G I G L C L L F I V R T L L L H P A I F G L H H I G M Q M R I A M F S L I Y K K T L K L S S R V L D K I S I G Q L V S L L S N N L N K F D E G L A L A H F V W I A P L Q V A L L M G L I W E L L Q A S A F C G L G F L I V L A L F Q A G L G R M M M K Y R D Q R A G K I S E R L V I T S E M I E N I Q S V K A Y C W E E A M E K M I E N L R Q T E L K L T R K A A Y V R Y F N S S A F F F S G F F V V F L S V L P Y A L I K G I I L R K I F T T I S F C I V L R M A V T R Q F P W A V Q T W Y D S L G A I N K I Q D F L Q K Q E Y K T L E Y N L T T T E V V M E N V T A F W E E G F G E L F E K A K Q N N N N R K T S N G D D S L F F S N F S L L G T P V L K D I N F K I E R G Q L L A V A G S T G A G K T S L L M V I M G E L E P S E G K I K H S G R I S F C S Q F S W I M P G T I K E N I I F G V S Y D E Y R Y R S V I K A C Q L E E D I S K F A E K D N I V L G E G G I T L S G G Q R A R I S L A R A V Y K D A D L Y L L D S P F G Y L D V L T E K E I F E S C V C K L M A N K T R I L V T S K M E H L K K A D K I L I L H E G S S Y F Y G T F S E L Q N L Q P D F S S K L M G C D S F D Q F S A E R R N S I L T E T L H R F S L E G D A P V S W T E T K K Q S F K Q T G E F G E K R K N S I L N P I N S I R K F S I V Q K T P L Q M N G I E E D S D E P L E R R L S L V P D S E Q G E A I L P R I S V I S T G P T L Q A R R R Q S V L N L M T H S V N Q G Q N I H R K T T A S T R K V S L A P Q A N L T E L D I Y S R R L S Q E T G L E I S E E I N E E D L K E C F F D D M E S I P A V T T W N T Y L R Y I T V H K S L I F V L I W C L V I F L A E V A A S L V V L W L L G N T P L Q D K G N S T H S R N N S Y A V I I T S T S S Y Y V F Y I Y V G V A D T L L A M G F F R G L P L V H T L I T V S K I L H H K M L H S V L Q A P M S T L N T L K A G G I L N R F S K D I A I L D D L L P L T I F D F I Q L L L I V I G A I A V V A V L Q P Y I F V A T V P V I V A F I M L R A Y F L Q T S Q Q L K Q L E S E G R S P I F T H L V T S L K G L W T L R A F G R Q P Y F E T L F H K A L N L H T A N W F L Y L S T L R W F Q M R I E M I F V I F F I A V T F I S I L T T G E G E G R V G I I L T L A M N I M S T L Q W A V N S S I D V D S L M R S V S R V F K F I D M P T E G K P T K S T K P Y K N G Q L S K V M I I E N S H V K K D D I W P S G G Q M T V K D L T A K Y T E G G N A I L E N I S F S I S P G Q R V G L L G R T G S G K S T L L S A F L R L L N T E G E I Q I D G V S W D S I T L Q Q W R K A F G V I P Q K V F I F S G T F R K N L D P Y E Q W S D Q E I W K V A D E V G L R S V I E Q F P G K L D F V L V D G G C V L S H G H K Q L M C L A R S V L S K A K I L L L D E P S A H L D P V T Y Q I I R R T L K Q A F A D C T V I L C E H R I E A M L E C Q Q F L V I E E N K V R Q Y D S I Q K L L N E R S L F R Q A I S P S D R V K L F P H R N S S K C K S K P Q I A A L K E E T E E E V Q D T R L
PTM type	X-Deubiquitination X-Glutathionylation X-N-glycosylation X-Phosphorylation X-Phosphorylation X-S-glutathionylation X-S-palmitoylation X-SUMOylation X-SUMOylation X-Ubiquitination X: Amino Acid

Deubiquitination
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Enhancing the endocytic recycling to the cell membrane of ABCC7			[1]
Role of PTM	Protein Activity Modulation
Related Enzyme	Ubiquitin carboxyl-terminal hydrolase 10 (USP10)
Experimental Material(s)	Human airway epithelial cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Deubiquitination at ABCC7 have been reported to enhance its endocytic recycling to the cell membrane.
Glutathionylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC7			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1344
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glutathionylation at ABCC7 Cystine 1344 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC7			[4]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	894
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC7 Asparagine 894 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC7			[4]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	900
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC7 Asparagine 900 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Affecting the activity of ABCC7			[5]
Role of PTM	Protein Activity Modulation
Modified Residue	Tyrosine	Modified Location	908
Modified State	Tyrosine to Asparagine substitution
Studied Phenotype	Cystic fibrosis [ICD11: CA25]
Experimental Material(s)	Baby hamster kidney (BHK) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at ABCC7 Tyrosine 908 (i.e. Tyrosine to Asparagine substitution) have been reported to affect its transport activity.
Phosphorylation
Serine	40 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Regulating the cAMP-responsive Cl- channel activity of the transporter			[6]
Role of PTM	Conformational Change
Modified Residue	Serine	Modified Location	660
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 660 have been reported to regulate its cAMP-responsive Cl- channel activity.
PTM Phenomenon2	Regulating the cAMP-responsive Cl- channel activity of the transporter			[6]
Role of PTM	Conformational Change
Modified Residue	Serine	Modified Location	737
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 737 have been reported to regulate its cAMP-responsive Cl- channel activity.
PTM Phenomenon3	Regulating the cAMP-responsive Cl- channel activity of the transporter			[6]
Role of PTM	Conformational Change
Modified Residue	Serine	Modified Location	795
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 795 have been reported to regulate its cAMP-responsive Cl- channel activity.
PTM Phenomenon4	Regulating the cAMP-responsive Cl- channel activity of the transporter			[6]
Role of PTM	Conformational Change
Modified Residue	Serine	Modified Location	813
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 813 have been reported to regulate its cAMP-responsive Cl- channel activity.
PTM Phenomenon5	Impairing the function of ABCC7			[7]
Role of PTM	Protein Activity Modulation
Modified Residue	Serine	Modified Location	1045
Modified State	Serine to Tyrosine substitution
Studied Phenotype	Cystic fibrosis [ICD11: CA25]
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the Phosphorylation at ABCC7 Serine 1045 (i.e. Serine to Tyrosine substitution) have been reported to impaire its transport function.
PTM Phenomenon6	Have the potential to influence ABCC7			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 4 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	45
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 45 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	45
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 45 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 50 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	256
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 256 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC7			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	422
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 422 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	427
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 427 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	427
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 427 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	427
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 427 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC7			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	466
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 466 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 489 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCC7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	492
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 492 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCC7			[10], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 511 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCC7			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	549
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 549 has the potential to affect its expression or activity.
PTM Phenomenon20	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	605
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Serine 605 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ABCC7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	641
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 641 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ABCC7			[15], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	670
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 670 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence ABCC7			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	686
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 686 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence ABCC7			[15], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	700
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 700 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence ABCC7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	707
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 707 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence ABCC7			[15], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	712
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 712 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence ABCC7			[19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	728
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 728 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence ABCC7			[15], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	753
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 753 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence ABCC7			[15], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	768
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 768 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence ABCC7			[20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	776
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 776 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence ABCC7			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	790
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 790 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence ABCC7			[8], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	809
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 809 has the potential to affect its expression or activity.
PTM Phenomenon33	Have the potential to influence ABCC7			[22], [23]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1248 has the potential to affect its expression or activity.
PTM Phenomenon34	Have the potential to influence ABCC7			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1255
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1255 has the potential to affect its expression or activity.
PTM Phenomenon35	Have the potential to influence ABCC7			[25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1359
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1359 has the potential to affect its expression or activity.
PTM Phenomenon36	Have the potential to influence ABCC7			[14], [25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1362
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1362 has the potential to affect its expression or activity.
PTM Phenomenon37	Have the potential to influence ABCC7			[26]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1426
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1426 has the potential to affect its expression or activity.
PTM Phenomenon38	Have the potential to influence ABCC7			[15], [27]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1444
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1444 has the potential to affect its expression or activity.
PTM Phenomenon39	Have the potential to influence ABCC7			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1455 has the potential to affect its expression or activity.
PTM Phenomenon40	Have the potential to influence ABCC7			[15], [29]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1456
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Serine 1456 has the potential to affect its expression or activity.
Threonine	17 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	94
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Threonine 94 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC7			[14], [25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	291
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 291 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC7			[8], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	421
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 421 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC7			[13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	501
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 501 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC7			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	547
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 547 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	582
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 582 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	604
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 604 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 682 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC7			[15], [27]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	717
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 717 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC7			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	774
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 774 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC7			[8], [21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	803
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 803 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	816
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Threonine 816 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	816
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Threonine 816 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCC7			[30]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 1171 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC7			[31]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 1176 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC7			[22], [23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1246
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 1246 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCC7			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1471
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Threonine 1471 has the potential to affect its expression or activity.
Tyrosine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC7			[10], [32]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Tyrosine 512 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC7			[14], [33]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Tyrosine 515 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	517
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Tyrosine 517 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	517
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Tyrosine 517 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC7			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	808
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Tyrosine 808 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1014
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CFTR Tyrosine 1014 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC7			[26]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1424
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC7 Tyrosine 1424 has the potential to affect its expression or activity.
S-glutathionylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CFTR			[34]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1344
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-glutathionylation (-SSG) at CFTR Cystine 1344 has the potential to affect its expression or activity.
S-palmitoylation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC7			[27]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	524
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at ABCC7 Cystine 524 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC7			[27]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1395
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at ABCC7 Cystine 1395 has the potential to affect its expression or activity.
SUMOylation
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at CFTR Lysine 447 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at CFTR Lysine 447 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at CFTR Lysine 447 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at CFTR Lysine 447 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at CFTR Lysine 447 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Enhancing the action of therapeutics that correct ABCC7 trafficking to the apical membranes			[35], [36]
Role of PTM	Surface Expression Modulation
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at ABCC7 have been reported to enhance its action of therapeutics that correct the transporter trafficking to the apical membranes.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC7			[27]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	688
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC7 Lysine 688 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing the expression and function of ABCC7			[37]
Role of PTM	Trafficking to Plasma Membrane
Related Enzyme	NEDD4-binding protein 2-like 2 (N4BP2L2)
Experimental Material(s)	(MPP+)-treated astrocytes
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC7 have been reported to decrease its expression and transport function.

References
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