Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID DTD0057 Transporter Info
Gene Name ABCC11
Transporter Name Multidrug resistance-associated protein 8
Gene ID
85320
UniProt ID
Q96J66
Post-Translational Modification of This DT
Sequence

N-linked glycosylation

  Asparagine

           3 PTM Phenomena Related to This Residue Click to Show/Hide the Full List

  PTM Phenomenon1

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Asparagine

Modified Location

 838

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 N-linked glycosylation at ABCC11 Asparagine 838 has the potential to affect its expression or activity.

  PTM Phenomenon2

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Asparagine

Modified Location

 844

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 N-linked glycosylation at ABCC11 Asparagine 844 has the potential to affect its expression or activity.

  PTM Phenomenon3

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Asparagine

Modified Location

 844

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 N-linked glycosylation at ABCC11 Asparagine 844 has the potential to affect its expression or activity.

Phosphorylation

  Serine

           2 PTM Phenomena Related to This Residue Click to Show/Hide the Full List

  PTM Phenomenon1

 . [2]

Role of PTM

 Potential impacts

Modified Residue

 Serine

Modified Location

 423

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 Phosphorylation at ABCC11 Serine 423 has the potential to affect its expression or activity.

  PTM Phenomenon2

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Serine

Modified Location

 1368

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 Phosphorylation at ABCC11 Serine 1368 has the potential to affect its expression or activity.

  Tyrosine

           3 PTM Phenomena Related to This Residue Click to Show/Hide the Full List

  PTM Phenomenon1

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Tyrosine

Modified Location

 64

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 Phosphorylation at ABCC11 Tyrosine 64 has the potential to affect its expression or activity.

  PTM Phenomenon2

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Tyrosine

Modified Location

 993

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 Phosphorylation at ABCC11 Tyrosine 993 has the potential to affect its expression or activity.

  PTM Phenomenon3

 . [1]

Role of PTM

 Potential impacts

Modified Residue

 Tyrosine

Modified Location

 993

Experimental Method

 Co-Immunoprecipitation

Detailed Description

 Phosphorylation at ABCC11 Tyrosine 993 has the potential to affect its expression or activity.
References
1 ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
2 15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.

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