Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0053 Transporter Info
Gene Name	ABCB7
Transporter Name	ABC transporter 7 protein
Gene ID	22
UniProt ID	O75027

Post-Translational Modification of This DT
Overview ofABCB7 Modification Sites with Functional and Structural Information
Sequence	M A L L A M H S W R W A A A A A A F E K R R H S A I L I R P L V S V S G S G P Q W R P H Q L G A L G T A R A Y Q I P E S L K S I T W Q R L G K G N S G Q F L D A A K A L Q V W P L I E K R T C W H G H A G G G L H T D P K E G L K D V D T R K I I K A M L S Y V W P K D R P D L R A R V A I S L G F L G G A K A M N I V V P F M F K Y A V D S L N Q M S G N M L N L S D A P N T V A T M A T A V L I G Y G V S R A G A A F F N E V R N A V F G K V A Q N S I R R I A K N V F L H L H N L D L G F H L S R Q T G A L S K A I D R G T R G I S F V L S A L V F N L L P I M F E V M L V S G V L Y Y K C G A Q F A L V T L G T L G T Y T A F T V A V T R W R T R F R I E M N K A D N D A G N A A I D S L L N Y E T V K Y F N N E R Y E A Q R Y D G F L K T Y E T A S L K S T S T L A M L N F G Q S A I F S V G L T A I M V L A S Q G I V A G T L T V G D L V M V N G L L F Q L S L P L N F L G T V Y R E T R Q A L I D M N T L F T L L K V D T Q I K D K V M A S P L Q I T P Q T A T V A F D N V H F E Y I E G Q K V L S G I S F E V P A G K K V A I V G G S G S G K S T I V R L L F R F Y E P Q K G S I Y L A G Q N I Q D V S L E S L R R A V G V V P Q D A V L F H N T I Y Y N L L Y G N I S A S P E E V Y A V A K L A G L H D A I L R M P H G Y D T Q V G E R G L K L S G G E K Q R V A I A R A I L K D P P V I L Y D E A T S S L D S I T E E T I L G A M K D V V K H R T S I F I A H R L S T V V D A D E I I V L D Q G K V A E R G T H H G L L A N P H S I Y S E M W H T Q S S R V Q N H D N P K W E A K K E N I S K E E E R K K L Q E E I V N S V K G C G N C S C
PTM type	X-Acetylation X-Malonylation X-Methylation X-O-glycosylation X-Phosphorylation X-Succinylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	211
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Asparagine 211 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Leucine 176 has the potential to affect its expression or activity.
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Lysine has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	216
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Lysine 216 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	251
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Lysine 251 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB7			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	499
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Lysine 499 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB7			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	608
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB7 Lysine 608 has the potential to affect its expression or activity.
Malonylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	216
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ABCB7 Lysine 216 has the potential to affect its expression or activity.
Methylation
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[6]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ABCB7 Arginine 10 has the potential to affect its expression or activity.
O-glycosylation
Serine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	461
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ABCB7 Serine 461 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	509
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ABCB7 Serine 509 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	466
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ABCB7 Threonine 466 has the potential to affect its expression or activity.
Phosphorylation
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[9]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	258
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Arginine 258 has the potential to affect its expression or activity.
Serine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	126
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 126 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	199
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 199 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	243
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 243 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB7			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	261
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 261 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB7			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 265 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCB7			[14], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	282
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 282 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCB7			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	370
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 370 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCB7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 489 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCB7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	492
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 492 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCB7			[9], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 540 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCB7			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	660
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 660 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCB7			[20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	743
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Serine 743 has the potential to affect its expression or activity.
Threonine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	257
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Threonine 257 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	371
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Threonine 371 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB7			[22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	446
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Threonine 446 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB7			[13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	600
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Threonine 600 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB7			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	636
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Threonine 636 has the potential to affect its expression or activity.
Tyrosine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[11], [24]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	196
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 196 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[17], [25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	286
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 286 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB7			[17], [25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	287
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 287 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB7			[26]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	340
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 340 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB7			[27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	345
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 345 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCB7			[27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	356
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Tyrosine 356 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[28]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	744
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB7 Valine 744 has the potential to affect its expression or activity.
Succinylation
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	251
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ABCB7 Lysine 251 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB7			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	361
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ABCB7 Lysine 361 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB7			[30]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	499
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ABCB7 Lysine 499 has the potential to affect its expression or activity.
Ubiquitination
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB7 Leucine 176 has the potential to affect its expression or activity.
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB7			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	216
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB7 Lysine 216 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB7 Lysine 500 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB7 Lysine 500 has the potential to affect its expression or activity.

References
1	Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40.
2	Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. 2012 Aug 30;2(2):419-31.
3	Perceived parental guan and school adjustment among Chinese early adolescents: The moderating role of interdependent self-construal. J Adolesc. 2019 Feb;71:18-27.
4	Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow. Mol Cell Proteomics. 2015 Sep;14(9):2429-40.
5	Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. Mol Cell Proteomics. 2015 Nov;14(11):3056-71.
6	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
7	Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag). Mol Cell Proteomics. 2018 Apr;17(4):764-775.
8	A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry. Chem Commun (Camb). 2018 Dec 6;54(98):13790-13793.
9	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
10	Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma. Mol Cell Proteomics. 2014 Apr;13(4):1034-49.
11	Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One. 2011 Jan 6;6(1):e15640.
12	An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics. Nat Commun. 2019 Feb 27;10(1):963.
13	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCB7_HUMAN)
14	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
15	Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson's Disease. Int J Mol Sci. 2022 Aug 18;23(16):9299.
16	Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach. Int J Mol Sci. 2022 Aug 18;23(16):9305.
17	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
18	Protection from excessive resuscitation: "pushing the pendulum back". J Trauma. 2000 Sep;49(3):567-8.
19	Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. Int J Mol Sci. 2014 Jul 7;15(7):12007-26.
20	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
21	Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression. Transplantation. 2000 Sep 15;70(5):760-4.
22	Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal. 2011 Jun 28;4(179):rs5.
23	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
24	The intracellular domain of beta-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity. Cell Death Dis. 2019 Feb 27;10(3):196.
25	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3.
26	A mechanochromic luminescent material with aggregation-induced emission: Application for pressure sensing and mapping. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Sep 5;220:117125.
27	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
28	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
29	Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress. Sci Rep. 2016 Jul 25;6:30212.
30	Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep. 2013 Aug 29;4(4):842-51.

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Detail Information of Post-Translational Modifications

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